Olverembatinib (HQP1351) in Combination with Lisaftoclax Overcomes Venetoclax Resistance in Preclinical Model of Acute Myeloid Leukemia (AML)

被引:0
|
作者
Xiong, Yan [1 ]
Liang, Zhiyan [2 ]
Min, Ping [1 ]
Wu, Bingxing [1 ]
Yu, Huidan [1 ]
Yang, Dajun [1 ,2 ,3 ]
Zhai, Yifan [1 ,2 ]
机构
[1] Ascentage Pharm Suzhou Co Ltd, Suzhou, Peoples R China
[2] Ascentage Pharm Grp Inc, Rockville, MD USA
[3] Sun Yat sen Univ, Collaborat Innovat Ctr Canc Med, Dept Expt Res, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Peoples R China
关键词
D O I
10.1182/blood-2024-202699
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:5777 / 5778
页数:2
相关论文
共 50 条
  • [41] Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia
    Bosc, Claudie
    Saland, Estelle
    Bousard, Aurelie
    Gadaud, Noemie
    Sabatier, Marie
    Cognet, Guillaume
    Farge, Thomas
    Boet, Emeline
    Gotanegre, Mathilde
    Aroua, Nesrine
    Mouchel, Pierre-Luc
    Polley, Nathaniel
    Larrue, Clement
    Kaphan, Eleonore
    Picard, Muriel
    Sahal, Ambrine
    Jarrou, Latifa
    Tosolini, Marie
    Rambow, Florian
    Cabon, Florence
    Nicot, Nathalie
    Poillet-Perez, Laura
    Wang, Yujue
    Su, Xiaoyang
    Fovez, Quentin
    Kluza, Jerome
    Arguello, Rafael Jose
    Mazzotti, Celine
    Avet-Loiseau, Herve
    Vergez, Francois
    Tamburini, Jerome
    Fournie, Jean-Jacques
    Tiong, Ing S.
    Wei, Andrew H.
    Kaoma, Tony
    Marine, Jean-Christophe
    Recher, Christian
    Stuani, Lucille
    Joffre, Carine
    Sarry, Jean-Emmanuel
    NATURE CANCER, 2021, 2 (11) : 1204 - +
  • [42] Preclinical Studies and Phase II Trial of Venetoclax in Combination with Chidamide and Azacitidine in Relapsed/Refractory Acute Myeloid Leukemia
    Zha, Jie
    Zhou, Hui
    Zhong, Mengya
    Wang, Ying
    Du, Xin
    Gong, Tiejun
    Lin, Zhijuan
    Cai, Yun
    Xie, Siting
    Xie, Chendi
    Feng, XianQi
    Huang, ZhenQi
    Su, Liping
    Luo, Jianmin
    Yang, Lin
    Li, Zhenling
    Chen, Bi-yun
    Xie, Ying
    Zhu, Yu
    Shi, Pengcheng
    Li, Zhifeng
    Jiang, Yirong
    Xu, Bing
    BLOOD, 2022, 140 : 3292 - 3293
  • [43] The preclinical efficacy of the novel hypomethylating agent NTX-301 as a monotherapy and in combination with venetoclax in acute myeloid leukemia
    Lim, Byungho
    Yoo, Dabin
    Chun, Younghwa
    Go, Areum
    Cho, Kyung-Jin
    Choi, Daeun
    Jung, Myoung Eun
    Lee, Ha Young
    Boohaker, Rebecca J.
    Lee, Jin Soo
    Jung, DooYoung
    Choi, Gildon
    BLOOD CANCER JOURNAL, 2022, 12 (04)
  • [44] Novel BCR-ABL1 Tyrosine Kinase Inhibitor (TKI) HQP1351 (Olverembatinib) Is Efficacious and Well Tolerated in Patients with T315I-Mutated Chronic Myeloid Leukemia (CML): Results of Pivotal (Phase II) Trials
    Jiang, Qian
    Huang, Xiaojun
    Chen, Zi
    Niu, Qian
    Shi, Dayu
    Li, Zongru
    Hou, Yue
    Hu, Yu
    Li, Weiming
    Liu, Xiaoli
    Xu, Na
    Song, Yongping
    Zhang, Yanli
    Meng, Li
    Hong, Zhenya
    Liu, Bingcheng
    Zeng, Shan
    Men, Lichuang
    Li, Yan
    Chen, Suning
    Xue, Mengxing
    Zhu, Huanling
    Li, He
    Du, Xin
    Lou, Jin
    Zhang, Xiaohan
    Liang, Yang
    Dai, Yujun
    Lu, Ming
    Wang, Hengbang
    Ji, Jiao
    Yue, Changai
    Yang, Dajun
    Zhai, Yifan
    BLOOD, 2020, 136
  • [45] The preclinical efficacy of the novel hypomethylating agent NTX-301 as a monotherapy and in combination with venetoclax in acute myeloid leukemia
    Byungho Lim
    Dabin Yoo
    Younghwa Chun
    Areum Go
    Kyung-Jin Cho
    Daeun Choi
    Myoung Eun Jung
    Ha Young Lee
    Rebecca J. Boohaker
    Jin Soo Lee
    DooYoung Jung
    Gildon Choi
    Blood Cancer Journal, 12
  • [46] ERK1/2 Inhibition Overcomes Resistance in Acute Myeloid Leukemia (AML) and Alters Mitochondrial Dynamics
    Sharma, Priyanka
    Piya, Sujan
    Ma, Huaxian
    Baran, Natalia
    Zal, Malgorzata Anna
    Hindley, Christopher J.
    Dao, Kim-Hien
    Sims, Martin
    Zal, Tomasz
    Ruvolo, Vivian
    Andreeff, Michael
    Borthakur, Gautam
    BLOOD, 2021, 138
  • [47] Olverembatinib (HQP1351) Demonstrates Efficacy Vs. Best Available Therapy (BAT) in Patients (Pts) with Tyrosine Kinase Inhibitor (TKI)-Resistant Chronic Myeloid Leukemia Chronic-Phase (CML-CP) in a Registrational Randomized Phase 2 Study
    Jiang, Qian
    Li, Zongru
    Zhang, Gongli
    Hu, Yu
    Li, Weiming
    Song, Yongping
    Li, Junmin
    Zhou, Li
    Liu, Bingcheng
    Liu, Xiaoli
    Xu, Na
    Chen, Suning
    Liu, Zhenfang
    Zhu, Huanling
    Jin, Jie
    Huang, He
    Qian, Sixuan
    Meng, Li
    Du, Xin
    Zhao, Xielan
    Gao, Sujun
    Liang, Yang
    Hou, Ming
    Wang, Wei
    Chen, Zi
    Niu, Qian
    Men, Lichuang
    Yang, Dajun
    Zhai, Yifan
    Huang, Xiaojun
    BLOOD, 2023, 142
  • [48] Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial (vol 15, 113, 2022)
    Jiang, Qian
    Li, Zongru
    Qin, Yazhen
    Li, Weiming
    Xu, Na
    Liu, Bingcheng
    Zhang, Yanli
    Meng, Li
    Zhu, Huanling
    Du, Xin
    Chen, Suning
    Liang, Yang
    Hu, Yu
    Liu, Xiaoli
    Song, Yongping
    Men, Lichuang
    Chen, Zi
    Niu, Qian
    Wang, Hengbang
    Lu, Ming
    Yang, Dajun
    Zhai, Yifan
    Huang, Xiaojun
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022, 15 (01)
  • [49] AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3- ITD acute myeloid leukemia
    Post, Sean M.
    Ma, Huaxian
    Malaney, Prerna
    Zhang, Xiaorui
    Aitken, Marisa J. L.
    Mak, Po Yee
    Ruvolo, Vivian R.
    Yasuhiro, Tomoko
    Kozaki, Ryohei
    Chan, Lauren E.
    Ostermann, Lauren B.
    Konopleva, Marina
    Carter, Bing Z.
    DiNardo, Courtney
    Andreeff, Michael D.
    Khoury, Joseph D.
    Ruvolo, Peter P.
    HAEMATOLOGICA, 2022, 107 (06) : 1311 - 1322
  • [50] Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial (vol 15, 159, 2022)
    Jiang, Qian
    Li, Zongru
    Qin, Yazhen
    Li, Weiming
    Xu, Na
    Liu, Bingcheng
    Zhang, Yanli
    Meng, Li
    Zhu, Huanling
    Du, Xin
    Chen, Suning
    Liang, Yang
    Hu, Yu
    Liu, Xiaoli
    Song, Yongping
    Men, Lichuang
    Chen, Zi
    Niu, Qian
    Wang, Hengbang
    Lu, Ming
    Yang, Dajun
    Zhai, Yifan
    Huang, Xiaojun
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2023, 16 (01)