Prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) Infection in Diabetic Foot Ulcer Patients in a Tertiary Care Centre

The study was conducted to observe the bacteriological profile of diabetic foot ulcers in patients at tertiary care hospital. The incidence and pattern of antibiotic resistance of MRSA was studied. A cross-sectional study was carried out in the tertiary care hospital from September 2017 to December 2021. Of a total of 313 DFU cases analysed, 304 cases were infected ulcers accounting for 97.13% of cases and the remaining 09 cases (2.87%) were noninfected. Of the isolates cultured from the infected ulcers, 261 (53.81%) were gram-negative organisms and 224 (46.18%) were gram-positive. Of the gram-positive organisms, Methicillin resistant Staphylococcus aureus (66.9%) was most common, followed by Methicillin sensitive Staphylococcus aureus (31.3%) and Streptococcus pyogenes (1.8%). Of the gram-negative organisms, Pseudomonas aeruginosa 67 (25.7%) was predominant, followed by Escherichia coli 53 (20.3%), Klebsiella species (19.2%), Acinetobacter species 50 (19.2%). The drug resistance pattern of MRSA was, Ofloxacin 82.6%, ciprofloxacin (89.3%), levofloxacin (91.3%), cefoxitin (100%) with Benzyl penicillin showing highest resistance of 100%. There was a significant rise of MRSA infections in DFUs.