Female reproductive tract microbiota varies with MHC profile

被引:1
|
作者
Leclaire, Sarah [1 ]
Bandekar, Mandar [2 ]
Rowe, Melissah [3 ]
Ritari, Jarmo [4 ]
Jokiniemi, Annalaura [2 ]
Partanen, Jukka [4 ]
Allinen, Pia [5 ]
Kuusipalo, Liisa [6 ]
Kekaelaeinen, Jukka [2 ]
机构
[1] Univ Toulouse, Ctr Rech Biodivers & Environm CRBE, Toulouse INP, CNRS,IRD,UMR5300, 118 Rte Narbonne, F-31062 Toulouse, France
[2] Univ Eastern Finland, Dept Environm & Biol Sci, POB 111, Joensuu 80101, Finland
[3] Netherlands Inst Ecol NIOO KNAW, Dept Anim Ecol, NL-6700 AB Wageningen, Netherlands
[4] Finnish Red Cross Blood Serv Res & Dev, Haartmaninkatu 8, Helsinki 00290, Finland
[5] Ovum Kuopio, Ajurinkatu 16, Kuopio 70110, Finland
[6] North Karelia Cent Hosp, Tikkamaentie 16, Joensuu 80210, Finland
关键词
major histocompatibility complex; reproduction; microbiome; health; MAJOR HISTOCOMPATIBILITY COMPLEX; IN-VITRO FERTILIZATION; VAGINAL MICROBIOME; DIVERSITY; IMPLANTATION; ASSOCIATION; PATTERNS; IMMUNITY; SUCCESS; QUALITY;
D O I
10.1098/rspb.2024.1334
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Numerous studies have shown that a healthy reproductive tract microbiota is crucial for successful reproduction and that its composition is influenced by various environmental and host factors. However, it is not known whether the reproductive microbiota is also shaped by the major histocompatibility complex (MHC), a family of genes essential to differentiate 'self' from 'non-self' peptides to initiate an adaptive immune response. We tested the association between the follicular fluid microbiome and MHC genes in 27 women. Women with higher MHC diversity had a higher microbiome diversity, characterized by bacteria commonly associated with vaginal dysbiosis. Women with similar MHC genes were also similar in their microbiome composition, indicating that MHC composition may be a key factor in determining the bacterial assemblage in the reproductive tract. Finally, the composition of the follicular fluid microbiome was similar to the vaginal microbiome, suggesting that numerous bacteria of the vagina are true inhabitants of the follicular fluid or that vaginal microbiota contaminated the follicular fluid microbiota during transvaginal collection. Collectively, our results demonstrate the importance of host genetic factors in shaping women's reproductive microbiota and they open the door for further research on the role of microbiota in mediating MHC-related variation in reproductive success.
引用
收藏
页数:11
相关论文
共 50 条
  • [21] Organoids of the female reproductive tract
    Cindrilla Chumduri
    Margherita Y. Turco
    Journal of Molecular Medicine, 2021, 99 : 531 - 553
  • [22] Organoids of the female reproductive tract
    Chumduri, Cindrilla
    Turco, Margherita Y.
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2021, 99 (04): : 531 - 553
  • [23] The Lumenal Microbiota Varies Biogeographically in the Gastrointestinal Tract of Rhesus Macaques
    Yan, Yaping
    Wang, Junfeng
    Qiu, Shuai
    Duan, Yanchao
    Si, Wei
    MICROBIOLOGY SPECTRUM, 2022, 10 (03):
  • [24] Female reproductive dysfunctions and the gut microbiota
    Chadchan, Sangappa B.
    Singh, Vertika
    Kommagani, Ramakrishna
    JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022, 69 (03) : R81 - R94
  • [25] The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases
    Chen Chen
    Xiaolei Song
    Weixia Wei
    Huanzi Zhong
    Juanjuan Dai
    Zhou Lan
    Fei Li
    Xinlei Yu
    Qiang Feng
    Zirong Wang
    Hailiang Xie
    Xiaomin Chen
    Chunwei Zeng
    Bo Wen
    Liping Zeng
    Hui Du
    Huiru Tang
    Changlu Xu
    Yan Xia
    Huihua Xia
    Huanming Yang
    Jian Wang
    Jun Wang
    Lise Madsen
    Susanne Brix
    Karsten Kristiansen
    Xun Xu
    Junhua Li
    Ruifang Wu
    Huijue Jia
    Nature Communications, 8
  • [26] Lymphocytes and MHC class II positive cells in the female rabbit reproductive tract before and after ovulation
    Gu, WY
    Janssens, P
    Holland, M
    Seamark, R
    Kerr, P
    IMMUNOLOGY AND CELL BIOLOGY, 2005, 83 (06): : 596 - 606
  • [27] Female reproductive tract microbiota and recurrent pregnancy loss: a nested case- control study
    Peuranpaea, Pirkko
    Holster, Tiina
    Saqib, Schahzad
    Kalliala, Ilkka
    Tiitinen, Aila
    Salonen, Anne
    Hautamaki, Hanna
    REPRODUCTIVE BIOMEDICINE ONLINE, 2022, 45 (05) : 1021 - 1031
  • [28] The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases
    Chen, Chen
    Song, Xiaolei
    Wei, Weixia
    Zhong, Huanzi
    Dai, Juanjuan
    Lan, Zhou
    Li, Fei
    Yu, Xinlei
    Feng, Qiang
    Wang, Zirong
    Xie, Hailiang
    Chen, Xiaomin
    Zeng, Chunwei
    Wen, Bo
    Zeng, Liping
    Du, Hui
    Tang, Huiru
    Xu, Changlu
    Xia, Yan
    Xia, Huihua
    Yang, Huanming
    Wang, Jian
    Wang, Jun
    Madsen, Lise
    Brix, Susanne
    Kristiansen, Karsten
    Xu, Xun
    Li, Junhua
    Wu, Ruifang
    Jia, Huijue
    NATURE COMMUNICATIONS, 2017, 8
  • [29] The Role of Microbiota in Human Reproductive Tract Cancers
    Walsh, Dana M.
    Mert, Ismail
    Chen, Jun
    Hou, Xiaonan
    Weroha, Saravut J.
    Chia, Nicholas
    Nelson, Heidi
    Mariani, Andrea
    Walther-Antonio, Marina R. S.
    AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 2019, 168 : 260 - 261
  • [30] Inflammation in the bovine female reproductive tract
    Bondurant, RH
    JOURNAL OF ANIMAL SCIENCE, 1999, 77 : 101 - 110