Kidney Protection by a Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor for a Mouse Model of Alport Syndrome

被引：0
|
作者：
Horizono, Jun [1 ]
Kaseda, Shota [1 ]
Sannomiya, Yuya [1 ]
Suico, Mary Ann [1 ]
Fukiya, Hirohiko [2 ]
Sunamoto, Hidetoshi [2 ]
Watanabe, Hiroshi [3 ]
Nakano, Takehiro [3 ]
Tokumaru, Kai [3 ]
Davenport, John Bernard
John, Bernard [4 ]
Shuto, Tsuyoshi [1 ]
Lennon, Rachel
Onuma, Kazuhiro [2 ]
Kai, Hirofumi [1 ]
机构：
[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, Dept Mol Med, Kumamoto, Kumamoto, Japan
[2] UBE Corp, Pharmaceut Res Lab, Yamaguchi, Japan
[3] Kumamoto Univ, Grad Sch Pharmaceut Sci, Dept Biopharmaceut, Kumamoto, Japan
[4] Univ Manchester, Wellcome Ctr Cell Matrix Res, Manchester, Lancs, England
来源：
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2024年 / 35卷 / 10期
关键词：
D O I：
10.1681/ASN.2024x8p67yq0
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
SA-PO640
引用
收藏
页数：2
相关论文
共 50 条
  • [21] KEAP1-NRF2 protein-protein interaction inhibitors: Design, pharmacological properties and therapeutic potential
    Crisman, Enrique
    Duarte, Pablo
    Dauden, Esteban
    Cuadrado, Antonio
    Rodriguez-Franco, Maria Isabel
    Lopez, Manuela G.
    Leon, Rafael
    MEDICINAL RESEARCH REVIEWS, 2023, 43 (01) : 237 - 287
  • [22] ELECTROPHILES AND KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION INHIBITORS FOR PREVENTION AND TREATMENT OF CHRONIC DISEASE
    Naidu, Sharadha Dayalan
    Dikovskaya, Dina
    Cafferkey, Annamarie J.
    Novak, Miroslav
    Suzuki, Takafumi
    Knatko, Elena V.
    Moore, Terry W.
    Wells, Geoffrey
    Dinkova-Kostova, Albena T.
    FREE RADICAL BIOLOGY AND MEDICINE, 2024, 218 : 3 - 3
  • [23] Novel Inhibitor of Keap1-Nrf2 Protein-Protein Interaction Attenuates Osteoclastogenesis In Vitro and Prevents OVX-Induced Bone Loss In Vivo
    Chen, Zhihao
    Yao, Hongyuan
    Encarnacion, Alessandra Marie
    Jeong, Jujin
    Choi, Yunju
    Park, Sangwook
    Lee, Sunwoo
    Lee, Taehoon
    ANTIOXIDANTS, 2024, 13 (07)
  • [24] Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction
    Begnini, Fabio
    Geschwindner, Stefan
    Johansson, Patrik
    Wissler, Lisa
    Lewis, Richard J.
    Danelius, Emma
    Luttens, Andreas
    Matricon, Pierre
    Carlsson, Jens
    Lenders, Stijn
    Konig, Beate
    Friedel, Anna
    Sjoe, Peter
    Schiesser, Stefan
    Kihlberg, Jan
    JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (04) : 3473 - 3517
  • [25] An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis
    Lu, Meng-Chen
    Ji, Jian-Ai
    Jiang, Yong-Lin
    Chen, Zhi-Yun
    Yuan, Zhen-Wei
    You, Qi-Dong
    Jiang, Zheng-Yu
    SCIENTIFIC REPORTS, 2016, 6
  • [26] An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis
    Meng-Chen Lu
    Jian-Ai Ji
    Yong-Lin Jiang
    Zhi-Yun Chen
    Zhen-Wei Yuan
    Qi-Dong You
    Zheng-Yu Jiang
    Scientific Reports, 6
  • [27] Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents
    Abed, Dhulfiqar Ali
    Goldstein, Melanie
    Albanyan, Haifa
    Jin, Huijuan
    Hu, Longqin
    ACTA PHARMACEUTICA SINICA B, 2015, 5 (04) : 285 - 299
  • [28] Modified Peptide Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction Incorporating Unnatural Amino Acids
    Georgakopoulos, Nikolaos D.
    Talapatra, Sandeep K.
    Gatliff, Jemma
    Kozielski, Frank
    Wells, Geoff
    CHEMBIOCHEM, 2018, 19 (17) : 1810 - 1816
  • [29] Updated Research and Applications of Small Molecule Inhibitors of Keap1-Nrf2 Protein-Protein Interaction: a Review
    Zhuang, Chunlin
    Miao, Zhenyuan
    Sheng, Chunquan
    Zhang, Wannian
    CURRENT MEDICINAL CHEMISTRY, 2014, 21 (16) : 1861 - 1870
  • [30] Computational Assessment of Carotenoids as Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Implications for Antioxidant Strategies
    Medoro, Alessandro
    Jafar, Tassadaq Hussain
    Sallustio, Fabio
    Scapagnini, Giovanni
    Saso, Luciano
    Davinelli, Sergio
    BIOCHEMISTRY-MOSCOW, 2024, 89 (10) : 1681 - 1691
12345