Pathophysiology of Prurigo Nodularis: Neuroimmune Dysregulation and the Role of Type 2 Inflammation

被引：0
|
作者：
Kwatra, Shawn G. [1 ,2 ]
Staender, Sonja [3 ,4 ]
Yosipovitch, Gil [5 ]
Kim, Brian S. [6 ]
Levit, Noah A. [7 ]
O'Malley, John T. [8 ]
机构：
[1] Univ Maryland, Sch Med, Dept Dermatol, Baltimore, MD USA
[2] Univ Maryland, Sch Med, Maryland Itch Ctr, Baltimore, MD USA
[3] Univ Hosp Munster, Dept Dermatol, Munster, Germany
[4] Univ Hosp Munster, Ctr Chron Pruritus, Munster, Germany
[5] Univ Miami, Miami Itch Ctr, Dr Philip Frost Dept Dermatol & Cutaneous Surg, Miami, FL USA
[6] Icahn Sch Med Mt Sinai, Mark Lebwohl Ctr Neuroinflammat & Sensat, Dept Dermatol, New York, NY USA
[7] Dermatol Phys Connecticut, Fairfield, CT USA
[8] Sanofi, 450 Water St, Cambridge, MA 02141 USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2025年 / 145卷 / 02期
关键词：
Neuroimmune axis; Pathophysiology; Prurigo nodularis; Type; 2; immunity; NERVE GROWTH-FACTOR; IMMUNOREACTIVE NERVES; TRIAL; PATHOGENESIS; NEMOLIZUMAB; EXPLORATION; BURDEN; ITCH; SKIN;
D O I：
10.1016/j.jid.2024.06.1276
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Prurigo nodularis (PN) is a chronic, inflammatory skin condition characterized by multiple, intensely pruritic, distinctive nodular lesions. Subsequent scratching can further intensify the pruritus, culminating in a self-reinforcing itch-scratch cycle, which drives lesion development. The latest data indicate dysregulation of the neuroimmune axis in PN pathogenesis, including the involvement of sensory neurons, key effector immune cells, proinflammatory cytokines, dermal fibroblasts, and pruritogens. In this review, we highlight evidence supporting the role of type 2 immune axis dysregulation in driving the clinical presentation of PN and discuss how related signaling pathways may offer effective therapeutic targets to control PN signs and symptoms.
引用
收藏
页码：249 / 256
页数：8
相关论文
共 50 条
  • [41] A Role for Inflammation in Intracranial Aneurysm Pathophysiology?
    Rahme, Rudy J.
    Bendok, Bernard R.
    NEUROSURGERY, 2010, 66 (06) : N14 - N15
  • [42] The role of neuroimmune and inflammation in pediatric uremia-induced neuropathy
    Zhu, Linfeng
    Tong, Guoqin
    Yang, Fan
    Zhao, Yijun
    Chen, Guangjie
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [43] Role of gut microbiota in type 2 diabetes pathophysiology
    Gurung, Manoj
    Li, Zhipeng
    You, Hannah
    Rodrigues, Richard
    Jump, Donald B.
    Morgun, Andrey
    Shulzhenko, Natalia
    EBIOMEDICINE, 2020, 51
  • [44] Incretins Role in the Pathophysiology of Type 2 Diabetes Mellitus
    Mythili, S., V
    RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 2015, 6 (06): : 698 - 702
  • [45] The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes
    Haedersdal, Sofie
    Lund, Asger
    Knop, Filip K.
    Vilsboll, Tina
    MAYO CLINIC PROCEEDINGS, 2018, 93 (02) : 217 - 239
  • [46] Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets
    Racca, Francesca
    Pellegatta, Gaia
    Cataldo, Giuseppe
    Vespa, Edoardo
    Carlani, Elisa
    Pelaia, Corrado
    Paoletti, Giovanni
    Messina, Maria Rita
    Nappi, Emanuele
    Canonica, Giorgio Walter
    Repici, Alessandro
    Heffler, Enrico
    FRONTIERS IN PHYSIOLOGY, 2022, 12
  • [47] Neuroimmune interplay during type 2 inflammation: Symptoms, mechanisms, and therapeutic targets in atopic diseases
    Kim, Brian
    Rothenberg, Marc E.
    Sun, Xin
    Bachert, Claus
    Artis, David
    Zaheer, Raza
    Deniz, Yamo
    Rowe, Paul
    Cyr, Sonya
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2024, 153 (04) : 879 - 893
  • [48] Emotion Dysregulation and Inflammation in African-American Women with Type 2 Diabetes
    Powers, Abigail
    Michopoulos, Vasiliki
    Conneely, Karen
    Gluck, Rachel
    Dixon, Hayley
    Wilson, Joseph
    Jovanovic, Tanja
    Pace, Thaddeus W. W.
    Umpierrez, Guillermo E.
    Ressler, Kerry J.
    Bradley, Bekh
    Gillespie, Charles F.
    NEURAL PLASTICITY, 2016, 2016
  • [49] Emerging role of innate B1 cells in the pathophysiology of autoimmune and neuroimmune diseases: Association with inflammation, oxidative and nitrosative stress and autoimmune responses
    Morris, Gerwyn
    Puri, Basant K.
    Olive, Lisa
    Carvalho, Andre F.
    Berk, Michael
    Maes, Michael
    PHARMACOLOGICAL RESEARCH, 2019, 148
  • [50] Serlopitant reduced pruritus in patients with prurigo nodularis in a phase 2, randomized, placebo-controlled trial
    Staender, Sonja
    Kwon, Paul
    Hirman, Joe
    Perlman, Andrew J.
    Weisshaar, Elke
    Metz, Martin
    Luger, Thomas A.
    Azimi, Nooshin
    Hutcheson, Nathan
    Israel-Hanniford, Davelene
    Agbonbhase, Amy
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2019, 80 (05) : 1395 - 1402
12345