Schistosomicidal Effects of Moringa oleifera Seed Oil Extract on Schistosoma mansoni-Infected Mice

被引：0
|
作者：
Elmalawany, Alshimaa M. [1 ]
Osman, Gamalat Y. [2 ]
Mohamed, Azza H. [2 ]
Khalaf, Fatema M. [2 ]
Yassien, Rania I. [3 ]
机构：
[1] Menoufia Univ, Natl Liver Inst, Clin Pathol Dept, Shibin Al Kawm, Egypt
[2] Menoufia Univ, Fac Sci, Zool Dept, Shibin Al Kawm, Egypt
[3] Menoufia Univ, Fac Med, Histol Dept, Shibin Al Kawm, Egypt
来源：
PARASITE IMMUNOLOGY | 2024年 / 46卷 / 11期
关键词：
antioxidant; cytokines; granuloma; <italic>M</italic>. <italic>o</italic><italic>leifera</italic> seed oil; PZQ; <italic>S</italic>. <italic>Mansoni</italic>; CATALYTIC CONCENTRATION; IFCC METHODS; ENZYMES; LEAVES; ASSAY;
D O I：
10.1111/pim.13070
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Schistosomiasis causes severe hepatic fibrosis, making it a global health issue. Moringa oleifera seed oil extract, which had antiparasitic, anti-inflammatory and antioxidant effects, was investigated as an alternative treatment. The 50 mice were divided into control, infected, praziquantel-treated, M. oleifera seed oil extract-treated and combined treatment groups. These treatments were examined for their effects on egg granulomas, hepatic enzymes, total protein, albumin, antioxidant enzymes and pro-inflammatory cytokines. M. oleifera seed oil and/or PZQ significantly reduced egg numbers, granuloma size and liver histopathology. M. oleifera seed oil reduced hepatic enzyme activity, increased total protein and albumin, and increased antioxidant enzyme activity while decreasing malondialdehyde. M. oleifera seed oil reduced the levels of pro-inflammatory cytokines. M. oleifera seed oil may treat schistosomiasis instead of PZQ due to its antifibrotic, immunomodulatory and schistosomicidal properties.
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页数：14
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