Antimicrobial Macrolide Levantilide D from Rare Marine Micromonospora sp.

被引：1

作者：

Zhao, Wei ^{[1
,2
]}

Zhou, Jian ^{[1
]}

Jiang, Honglei ^{[1
]}

Ge, Yichao ^{[2
]}

Zhou, Jingming ^{[1
]}

Zhao, Meilu ^{[2
]}

Lin, Ru ^{[1
]}

Jiang, Hong ^{[1
]}

Wu, Bin ^{[2
]}

机构：

[1] Fujian Inst Microbiol, Fujian Prov Key Lab Screening Novel Microbial Prod, Fuzhou 350007, Peoples R China

[2] Zhejiang Univ, Ocean Coll, Hangzhou 310058, Peoples R China

来源：

NATURAL PRODUCTS JOURNAL | 2024年

关键词：

Levantilide C and D; marine natural products; Micromonospora sp; quantum chemical calculations; putative biosynthetic pathway;

D O I：

10.2174/0122103155325417241001112138

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Introduction: One new levantilide D (2) with a 20-membered macrolide, along with one known levantilide C (1), was isolated from a rare marine actinomycetes Micromonospora sp. (FIMYZ52). Method: The structural elucidation of the compounds was based on integrated analyses involving 1D and 2D NMR spectroscopy and HR-ESI-MS. Result: The relative and absolute configurations of compounds 1 and 2 were ascertained by integrating multispectral ROESY and NOESY information from analogs in conjunction with theoretical TDDFT-ECD calculations. Levantilide D (2) exhibited antibacterial activity against Staphylococcus aureus. Conclusion: A plausible biosynthetic pathway of the macrolide compounds (1-2) was proposed.

引用

页数：8

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