The role of cGAS-STING in remodeling the tumor immune microenvironment induced by radiotherapy

被引：0

作者：

Jiang, Qingyu ^{[1
,2
,3
,4
]}

Chen, Zhiheng ^{[5
]}

Jiang, Jin ^{[5
]}

Chen, Qianping ^{[1
,3
,4
]}

Lan, Huiyin ^{[1
,3
,4
]}

Zhu, Ji ^{[1
,3
,4
]}

Mao, Wei ^{[1
,3
,4
]}

机构：

[1] Zhejiang Canc Hosp, Dept Radiat Oncol, Hangzhou 310000, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Hangzhou 310053, Peoples R China

[3] Chinese Acad Sci, Hangzhou Inst Med HIM, Hangzhou 310000, Peoples R China

[4] Zhejiang Key Lab Radiat Oncol, Hangzhou 310000, Peoples R China

[5] Jiaxing Univ, Hosp Jiaxing 1, Affiliated Hosp, Dept Oncol, Jiaxing, Peoples R China

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2025年 / 209卷

基金：

中国国家自然科学基金;

关键词：

Radiotherapy; Tumor immune microenvironment; CGAS-STING pathway; DENDRITIC CELLS; RADIATION; CANCER; IMMUNOTHERAPY; PROMOTES; PATHWAY; OPPORTUNITIES; SURVIVAL; DEATH; IDO;

D O I：

10.1016/j.critrevonc.2025.104658

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The activation of the cGAS-STING pathway occurs when tumor cell DNA is damaged by ionizing radiation. Once triggered, this pathway reshapes the tumor immune microenvironment by promoting the maturation, activation, polarization, and immune-killing capacity of immune cells, as well as by inducing the release of interferons and the expression of immune-related genes. In addition, the gut microbiota and various mechanisms of programmed cell death interact with the cGAS-STING pathway, further influencing its function in remodeling the immune microenvironment after radiotherapy. Therefore, investigating the mechanisms of the cGAS-STING pathway in reshaping the tumor immune microenvironment post-radiotherapy can not only optimize the efficacy of combined radiotherapy and immunotherapy but also provide new research directions and potential targets for cancer treatment.

引用

页数：14

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