Enantioselective Decarboxylative Mannich Reactions of α,β-Unsaturated β′-Ketoacids and Isatin Imines: Application in the Synthesis of Spiro[indoline-3,2′-piperidine]-2,4′-diones

被引：0

作者：

Venugopal, Hrishikesh Devaki Sadanam ^{[1
]}

Pansare, Sunil V. ^{[1
]}

机构：

[1] Mem Univ Newfoundland, Dept Chem, St John, NF A1B 3X7, Canada

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 05期

基金：

加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

ASYMMETRIC-SYNTHESIS; DERIVATIVES; SPIROOXINDOLES;

D O I：

10.1021/acs.orglett.4c04675

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Organocatalytic, enantioselective decarboxylative Mannich reactions of alpha,beta-unsaturated beta '-ketoacids and isatin N-Boc imines, to give the corresponding 3-carbamoyl-2-oxindole derivatives, were developed. Subsequent N-deprotection and diastereoselective, intramolecular, aza-Michael reaction of the free amine provides previously unreported spiro[indoline-3,2 '-piperidine]-2,4 '-diones.

引用

页码：1170 / 1174

页数：5

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