A Genome-Wide High-Throughput Gain-of-Function Screen Identifies Novel Targets for Improved AAV9 Production

被引：0
|
作者：
Wang, Chad [1 ]
Sheth, Muskan [1 ]
Ispaso, Francesca [1 ]
Ukani, Isha [1 ]
Horer, Markus [2 ]
Mandegar, Mo [1 ]
Reid, Chris A. [1 ]
机构：
[1] Ascend Gene & Cell Therapies, Alameda, CA USA
[2] Ascend Gene & Cell Therapies, Planegg, Germany
来源：
MOLECULAR THERAPY | 2024年 / 32卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
1505
引用
收藏
页码：708 / 708
页数：1
相关论文
共 50 条
  • [31] A genome-wide RNAi screen identifies novel targets of neratinib resistance leading to identification of potential drug resistant genetic markers
    Seyhan, Attila A.
    Varadarajan, Usha
    Choe, Sung
    Liu, Wei
    Ryan, Terence E.
    MOLECULAR BIOSYSTEMS, 2012, 8 (05) : 1553 - 1570
  • [32] A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance
    Dimberg, Lina Y.
    Towers, Christina G.
    Behbakht, Kian
    Hotz, Taylor J.
    Kim, Jihye
    Fosmire, Susan
    Porter, Christopher C.
    Tan, Aik-Choon
    Thorburn, Andrew
    Ford, Heide L.
    MOLECULAR CANCER RESEARCH, 2017, 15 (04) : 382 - 394
  • [33] Complementary Genome-Wide, Loss- and Gain-of-Function Screens Discover Novel Genes Associated with Platinum Resistance in Colon Adenocarcinoma
    Dogeas, Epameinondas
    Chen, Beibei
    Xie, Yang
    Mendell, Joshua
    Augustine, Mathew M.
    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2017, 225 (04) : S187 - S188
  • [34] A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer
    Malene Blond Ipsen
    Ea Marie Givskov Sørensen
    Emil Aagaard Thomsen
    Simone Weiss
    Jakob Haldrup
    Anders Dalby
    Johan Palmfeldt
    Peter Bross
    Martin Rasmussen
    Jacob Fredsøe
    Søren Klingenberg
    Mads R. Jochumsen
    Kirsten Bouchelouche
    Benedicte Parm Ulhøi
    Michael Borre
    Jacob Giehm Mikkelsen
    Karina Dalsgaard Sørensen
    Oncogene, 2022, 41 : 4271 - 4281
  • [35] A genome-wide CRISPR-Cas9 knockout screen identifies novel PARP inhibitor resistance genes in prostate cancer
    Ipsen, Malene Blond
    Sorensen, Ea Marie Givskov
    Thomsen, Emil Aagaard
    Weiss, Simone
    Haldrup, Jakob
    Dalby, Anders
    Palmfeldt, Johan
    Bross, Peter
    Rasmussen, Martin
    Fredsoe, Jacob
    Klingenberg, Soren
    Jochumsen, Mads R.
    Bouchelouche, Kirsten
    Ulhoi, Benedicte Parm
    Borre, Michael
    Mikkelsen, Jacob Giehm
    Sorensen, Karina Dalsgaard
    ONCOGENE, 2022, 41 (37) : 4271 - 4281
  • [36] Genome-Wide Investigation of MicroRNAs and Their Targets in Response to Freezing Stress in Medicago sativa L., Based on High-Throughput Sequencing
    Shu, Yongjun
    Liu, Ying
    Li, Wei
    Song, Lili
    Zhang, Jun
    Guo, Changhong
    G3-GENES GENOMES GENETICS, 2016, 6 (03): : 755 - 765
  • [37] A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp
    Rotordam, Maria G.
    Fermo, Elisa
    Becker, Nadine
    Barcellini, Wilma
    Brueggemann, Andrea
    Fertig, Niels
    Egee, Stephane
    Rapedius, Markus
    Bianchi, Paola
    Kaestner, Lars
    HAEMATOLOGICA, 2019, 104 (05) : E179 - E183
  • [38] Inferring genome-wide functional linkages in E-coli by combining improved genome context methods:: Comparison with high-throughput experimental data
    Yellaboina, Sailu
    Goyal, Kshama
    Mande, Shekhar C.
    GENOME RESEARCH, 2007, 17 (04) : 527 - 535
  • [39] A genome-wide high-complexity shRNA library screen identifies novel factors in MHC class I trafficking and degradation
    van de Weijer, Michael L.
    Bassik, Michael C.
    Luteijn, Rutger D.
    Hoelen, Hanneke
    Ressing, Maaike E.
    Hoeben, Rob C.
    Weissman, Jonathan S.
    McManus, Michael T.
    Lebbink, Robert Jan
    Wiertz, Emmanuel
    MOLECULAR IMMUNOLOGY, 2015, 68 (02) : 148 - 149
  • [40] Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma
    Xing, Hui
    Gao, Mengshi
    Wang, Yuxiang
    Zhang, Xu
    Shi, Jiajie
    Wang, Xiang
    Liu, Xueling
    Ma, Qingyang
    Kong, Xiangyin
    Yang, Chunhao
    Ding, Jian
    Meng, Linghua
    CLINICAL AND TRANSLATIONAL MEDICINE, 2022, 12 (05):
12345