Ru(<sc>ii</sc>)-catalyzed oxidative C-H spiroannulation of 4-arylquinazolin-2-ones with alkynes

被引：0
|
作者：
Ajay, Chidrawar [1 ,3 ]
Sridhar, B. [2 ,3 ]
Reddy, B. V. Subba [1 ,3 ]
机构：
[1] CSIR Indian Inst Chem Technol, Fluoro & Agrochem, Hyderabad 500007, India
[2] CSIR Indian Inst Chem Technol, Lab X ray Crystallog, Hyderabad 500007, India
[3] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年
关键词：
CATALYZED 3+2 ANNULATION; N-SULFONYL KETIMINES; BOND ACTIVATION; POTENT; SPIROQUINAZOLINONES; INHIBITOR; MECHANISM; DISCOVERY; INSERTION; DESIGN;
D O I：
10.1039/d5ob00170f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel strategy has been devised for the synthesis of spiro[indene-1,4 '-quinazolin]-2 '(3 ' H)-one frameworks through Ru(ii)-catalyzed tandem ortho-C-H bond activation and spiroannulation of 4-arylquinazolin-2-ones with alkynes. This is the first example of spiroannulation of 4-arylquinazolin-2-ones with internal alkynes. It is a versatile approach for synthesizing spiro[indene-1,4 '-quinazolin]-2 '(3 ' H)-one scaffolds with a broad substrate scope and high functional group tolerance.
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页数：6
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