Ortho-Functionalization of Pillar[4]arene[1]benzoquinone Monoxime via Selective 1,4-Addition of Grignard Reagents

被引：0

作者：

Xu, Yuxuan ^{[1
]}

Li, Runmei ^{[2
]}

Liang, Fengjun ^{[2
]}

Peng, Xiaolong ^{[2
]}

Liu, Yahu A. ^{[3
]}

Jia, Fei ^{[2
]}

Wen, Ke ^{[1
,2
,4
]}

机构：

[1] Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China

[2] Yanan Univ, Coll Chem & Chem Engn, Yanan 716000, Peoples R China

[3] ChemBridge Res Labs, Med Chem, San Diego, CA 92127 USA

[4] Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 06期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/acs.orglett.4c04564

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ortho-functionalization of pillar[n]arenes has been a formidable challenge, partially due to the fragility of their macrocyclic skeletons. In this concise report, we describe a facile synthetic method for monoarylation/alkylation at the position ortho to the oxime functionality in pillar[4]arene[1]benzoquinone monoxime (1) via addition of Grignard reagents. The described method enables the creation of various mono-ortho-alkyl/aryl-substituted pillar[5]arene derivatives that were previously inaccessible.

引用

页码：1367 / 1371

页数：5

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