Ortho-Functionalization of Pillar[4]arene[1]benzoquinone Monoxime via Selective 1,4-Addition of Grignard Reagents

被引：0
|
作者：
Xu, Yuxuan [1 ]
Li, Runmei [2 ]
Liang, Fengjun [2 ]
Peng, Xiaolong [2 ]
Liu, Yahu A. [3 ]
Jia, Fei [2 ]
Wen, Ke [1 ,2 ,4 ]
机构：
[1] Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
[2] Yanan Univ, Coll Chem & Chem Engn, Yanan 716000, Peoples R China
[3] ChemBridge Res Labs, Med Chem, San Diego, CA 92127 USA
[4] Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China
来源：
ORGANIC LETTERS | 2025年 / 27卷 / 06期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1021/acs.orglett.4c04564
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ortho-functionalization of pillar[n]arenes has been a formidable challenge, partially due to the fragility of their macrocyclic skeletons. In this concise report, we describe a facile synthetic method for monoarylation/alkylation at the position ortho to the oxime functionality in pillar[4]arene[1]benzoquinone monoxime (1) via addition of Grignard reagents. The described method enables the creation of various mono-ortho-alkyl/aryl-substituted pillar[5]arene derivatives that were previously inaccessible.
引用
收藏
页码：1367 / 1371
页数：5
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