Applications, Limitations, and Considerations of Clinical Trials in a Dish

被引：0

作者：

Mir, Amatullah ^{[1
]}

Zhu, Angie ^{[1
]}

Lau, Rico ^{[1
]}

Barr, Nicolas ^{[1
]}

Sheikh, Zyva ^{[1
]}

Acuna, Diana ^{[1
]}

Dayal, Anuhya ^{[1
]}

Hibino, Narutoshi ^{[1
,2
]}

机构：

[1] Univ Chicago, Dept Surg, Sect Cardiac Surg, 5841 S Maryland Ave, Chicago, IL 60637 USA

[2] Advocate Childrens Hosp, Pediat Cardiac Surg, 4440 W 95th St, Oak Lawn, IL 60453 USA

来源：

BIOENGINEERING-BASEL | 2024年 / 11卷 / 11期

关键词：

iPSCs; organ-on-a-chip; clinical trials in dish; bioprinting; tissue engineering; vasculature; 3D modeling; scaffolds; spheroids; 3D printing; vascularization; hard tissue; stem cells; biomechanics; 3D-printed sensors; bioinks; 3D tissues; soft tissue;

D O I：

10.3390/bioengineering11111096

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent advancements in biotechnology forged the path for clinical trials in dish (CTiDs) to advance as a popular method of experimentation in biomedicine. CTiDs play a fundamental role in translational research through technologies such as induced pluripotent stem cells, whole genome sequencing, and organs-on-a-chip. In this review, we explore advancements that enable these CTiD biotechnologies and their applications in animal testing, disease modeling, and space radiation technologies. Furthermore, this review dissects the advantages and disadvantages of CTiDs, as well as their regulatory considerations. Lastly, we evaluate the challenges that CTiDs pose and the role of CTiDs in future experimentation.

引用

页数：16

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