Evaluating the Genotoxicity of Small-Molecule Nitrosamines and Nitrosamine Drug Substance-Related Impurities in 2D and 3D HepaRG Cell Models

被引：0
|
作者：
Xu, Hannah [1 ]
Seo, Ji-Eun [1 ]
Li, Xilin [1 ]
Mei, Nan [1 ]
Heflich, Robert [1 ]
Atrakchi, Aisar H. [2 ]
McGovern, Timothy J. [2 ]
Bruno, Karen L. Davis [2 ]
Guo, Xiaoqing [1 ]
机构：
[1] US FDA, Div Genet & Mol Toxicol, Natl Ctr Toxicol Res, Jefferson, AR USA
[2] US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD USA
来源：
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2024年 / 65卷
关键词：
D O I：
暂无
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
PS100
引用
收藏
页码：109 / 110
页数：2
相关论文
共 50 条
  • [1] Genotoxicity assessment of eight nitrosamine impurities using 2D and 3D HepaRG cell models
    Xu, Hannah S.
    Seo, Jieun
    Guo, Xiaoqing
    Mei, Nan
    Heflich, Robert
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2023, 64 : 14 - 14
  • [2] Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
    Ji-Eun Seo
    Joshua Z. Yu
    Hannah Xu
    Xilin Li
    Aisar H. Atrakchi
    Timothy J. McGovern
    Karen L. Davis Bruno
    Nan Mei
    Robert H. Heflich
    Xiaoqing Guo
    Archives of Toxicology, 2023, 97 : 2785 - 2798
  • [3] Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
    Seo, Ji-Eun
    Yu, Joshua Z.
    Xu, Hannah
    Li, Xilin
    Atrakchi, Aisar H.
    McGovern, Timothy J.
    Bruno, Karen L. Davis
    Mei, Nan
    Heflich, Robert H.
    Guo, Xiaoqing
    ARCHIVES OF TOXICOLOGY, 2023, 97 (10) : 2785 - 2798
  • [4] Study of Genotoxicity of NanomaterialFs Using 2D and 3D HepaRG Liver Cell Models.
    Varet, J.
    Crochet, C.
    Le Hegarat, L.
    Fessard, V
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2021, 62 : 82 - 82
  • [5] Comparison of 2D and 3D cell cultures of colorectal adenocarcinoma as models for drug screening
    Poloznikov, A. A.
    Nikulin, S. V.
    Bolotina, L. V.
    Gaisina, I. N.
    Alexeev, B. Ya.
    RUSSIAN CHEMICAL BULLETIN, 2019, 68 (12) : 2377 - 2380
  • [6] Comparison of 2D and 3D cell cultures of colorectal adenocarcinoma as models for drug screening
    A. A. Poloznikov
    S. V. Nikulin
    L. V. Bolotina
    I. N. Gaisina
    B. Ya. Alexeev
    Russian Chemical Bulletin, 2019, 68 : 2377 - 2380
  • [7] Comparison of 2D and 3D cell culture models for cell growth, gene expression and drug resistance
    Fontoura, Julia C.
    Viezzer, Christian
    dos Santos, Fabiana G.
    Ligabue, Rosane A.
    Weinlich, Ricardo
    Puga, Renato D.
    Antonow, Dyeison
    Severino, Patricia
    Bonorino, Cristina
    MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2020, 107
  • [8] Evaluating the mutagenicity in 2D and 3D HepaRG cell cultures using errorcorrected next generation sequencing: a proof-of-concept study
    Guo, Xiaoqing
    Seo, Ji-Eun
    Revollo, Javier
    Miranda-Colon, Jaime
    Xu, Hannah
    Heflich, Robert
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2024, 65 : 13 - 13
  • [9] From 2D to 3D Cancer Cell Models-The Enigmas of Drug Delivery Research
    Van Zundert, Indra
    Fortuni, Beatrice
    Rocha, Susana
    NANOMATERIALS, 2020, 10 (11) : 1 - 30
  • [10] Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
    Ji-Eun Seo
    Yuan Le
    Javier Revollo
    Jaime Miranda-Colon
    Hannah Xu
    Page McKinzie
    Nan Mei
    Tao Chen
    Robert H. Heflich
    Tong Zhou
    Timothy Robison
    Jessica A. Bonzo
    Xiaoqing Guo
    Archives of Toxicology, 2024, 98 : 1919 - 1935
12345