Electrochemical Synthesis of Quinazolines: N-H/C(sp3)-H Coupling of o-Carbonyl Anilines with Amino Acids and Amines

被引：0

作者：

Wu, Jiwei ^{[1
]}

Yu, Lingxiang ^{[1
]}

Li, Kaixuan ^{[1
]}

Zhang, Di ^{[1
]}

Ye, Longqiang ^{[1
]}

Xu, Xiaolan ^{[2
]}

Zhou, Jie ^{[3
]}

Li, Zirong ^{[1
]}

Xu, Huajian ^{[3
]}

机构：

[1] Anhui Sci & Technol Univ, Coll Chem & Mat Engn, Fengyang 233100, Peoples R China

[2] Anhui Med Univ, Sch Med Sci, Hefei 230009, Peoples R China

[3] Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 23期

基金：

中国国家自然科学基金;

关键词：

H BOND; DERIVATIVES; AMINATION; 2-ARYLQUINAZOLINES; CANCER; ANNULATION;

D O I：

10.1021/acs.joc.4c01173

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient electrochemical protocol for the synthesis of quinazolines through N-H/C(sp3)-H coupling of o-carbonyl anilines with natural amino acids/amines has been developed. The products quinazolines can easily be isolated in moderate to excellent yields under external chemical oxidant-free conditions. Moreover, this reaction can be safely conducted on gram scale.

引用

页码：17031 / 17041

页数：11

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