Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to Treatment

被引：0
|
作者：
Bai, Samantha H. [1 ]
Chandnani, Arun [1 ]
Cao, Siyan [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Med, Div Gastroenterol, St Louis, MO 63110 USA
来源：
BIOMEDICINES | 2024年 / 12卷 / 12期
关键词：
bile acids; inflammatory bowel disease; ulcerative colitis; Crohn's disease; pathogenesis; new therapies; FARNESOID X RECEPTOR; PRIMARY SCLEROSING CHOLANGITIS; GUT MICROBIOTA; INTESTINAL INFLAMMATION; URSODEOXYCHOLIC ACID; ULCERATIVE-COLITIS; MICE; METABOLITES; REVEAL; ASSOCIATION;
D O I：
10.3390/biomedicines12122910
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inflammatory bowel disease (IBD) is a chronic condition that affects about 7 million people worldwide, and new therapies are needed. Understanding the complex roles that bile acids (BAs) play in IBD may lead to the development of novel IBD treatments independent of direct immunosuppression. This review discusses the latest discoveries in the roles BAs play in IBD pathogenesis and explores how these discoveries offer promising new therapeutic targets to treat IBD and improve patient outcomes. Several therapies discussed include specific BA receptor (BAR) agonists, dietary therapies, supplements, probiotics, and mesenchymal stem cell therapies that have all been shown to decrease IBD disease activity.
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页数：24
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