Properties of Hippocampal Mossy Fibre Synapses in VAMP7 KO Mice

被引：0

作者：

Llinares, Bernat Gonzalez i ^{[1
,2
]}

Danglot, Lydia ^{[3
]}

Galli, Thierry ^{[3
,4
]}

Mulle, Christophe ^{[1
,2
]}

机构：

[1] Interdisciplinary Inst Neurosci, CNRS UMR 5297, Bordeaux, France

[2] Univ Bordeaux, Bordeaux, France

[3] Univ Paris Cite, Inst Psychiat & Neurosci Paris, INSERM U1266, Membrane Traff Hlth & Diseased Brain, Paris, France

[4] Grp Hosp Univ GHU Paris Psychiat & Neurosci, Paris, France

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2025年 / 61卷 / 04期

关键词：

hippocampus; mossy fibre synapses; presynaptic mechanisms; VAMP7; v-SNARE; MEMBRANE-PROTEIN; SNARE; TI-VAMP/VAMP7; SECRETION; VESICLES; LOCALIZATION; MACHINERY; COMPLEXES; TRANSPORT; DYNAMICS;

D O I：

10.1111/ejn.70016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

VAMP7 is a vesicular SNARE of the longin family that localizes to axons and dendrites during development, where it is important in neurite growth. In the adult brain, VAMP7 is enriched in a subset of nerve terminals, particularly in hippocampal mossy fibres (Mfs) originating from the dentate gyrus. We analysed the VAMP7 function in neurotransmitter release by detailed functional characterization of Mf synapses onto CA3 pyramidal cells in knockout mutant mice for VAMP7. We have evaluated the role of VAMP7 in different forms of short-term synaptic plasticity and the potential contribution of the co-release of glutamate and zinc. This analysis has not revealed any significant impact of the loss of VAMP7 for basal properties of synaptic transmission, for short-term plasticity, for asynchronous release and for the ability of Mf vesicles to release ionic zinc. Based on these findings, the potential role of VAMP7 in the regulation of presynaptic mechanisms is discussed.

引用

页数：14