Organoids in skin wound healing

被引：0

作者：

Wang, Zitong ^{[1
]}

Zhao, Feng ^{[2
]}

Lang, Hongxin ^{[2
]}

Ren, Haiyue ^{[3
]}

Zhang, Qiqi ^{[4
]}

Huang, Xing ^{[5
]}

He, Cai ^{[1
]}

Xu, Chengcheng ^{[1
]}

Tan, Chiyu ^{[1
]}

Ma, Jiajie ^{[1
]}

Duan, Shu ^{[1
]}

Wang, Zhe ^{[1
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Pathol, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China

[2] China Med Univ, Dept Stem Cells & Regenerat Med, Shenyang Key Lab Stem Cell & Regenerat Med, 77 Puhe Rd, Shenyang 110013, Liaoning, Peoples R China

[3] Wuhan Hosp Tradit Chinese & Western Med, Wuhan 1 Hosp, Dept Pathol, 215 Zhongshan St, Wuhan 430022, Hubei, Peoples R China

[4] Chengdu Third Peoples Hosp, Dept Pathol, 82 Qinglong St, Chengdu 610031, Sichuan, Peoples R China

[5] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Anaesthesiol, 277 Yantaxi Rd, Xian 710061, Shanxi, Peoples R China

来源：

BURNS & TRAUMA | 2025年 / 13卷

基金：

中国国家自然科学基金;

关键词：

Skin organoids; Tissue engineering; Pluripotent stem cells; Skin wound healing; PLURIPOTENT STEM-CELLS; HAIR FOLLICLE; GENERATION; DIFFERENTIATION; KERATINOCYTES; EPITHELIA; HYDROGELS; BIOBANK;

D O I：

10.1093/burnst/tkae077

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Stem cells (SCs) can self-replicate and differentiate into multiple lineages. Organoids, 3D cultures derived from SCs, can replicate the spatial structure and physiological characteristics of organs in vitro. Skin organoids can effectively simulate the physiological structure and function of skin tissue, reliably restoring the natural skin ecology in various in vitro environments. Skin organoids have been employed extensively in skin development and pathology research, offering valuable insights for drug screening. Moreover, they play crucial roles in skin regeneration and tissue repair. This in-depth review explores the construction and applications of skin organoids in wound healing, with a focus on their construction process, including skin appendage integration, and significant advancements in wound-healing research.

引用

页数：13

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