MRI detects tubulointerstitial changes in mouse models of radiation-induced nephropathy

被引：0

作者：

Stabinska, Julia ^{[1
,2
]}

Piccolo, Joe ^{[2
]}

Chhabra, Anupriya ^{[2
]}

Liatsou, Ioanna ^{[2
]}

Gabrielson, Kathy ^{[3
]}

Li, Zhi ^{[2
]}

Mohanta, Zinia ^{[1
,2
]}

Sedaghat, Farzad ^{[2
]}

Hobbs, Robert F. ^{[2
]}

Sgouros, George ^{[2
]}

Mcmahon, Michael T. ^{[1
,2
]}

机构：

[1] Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, 707 N Broadway, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 2025年

基金：

美国国家卫生研究院;

关键词：

actinium-225; external beam radiotherapy; kidney; MRI; radiation nephropathy; RELAXATION-TIME; KIDNEY; TISSUE;

D O I：

10.1002/mrm.30443

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose We hypothesized that radiation-induced tubulointerstitial changes in the kidney can be assessed using MRI-based T-2 relaxation time measurements. Methods We performed MRI, histology, and serum biochemistry in two mouse models of radiation nephropathy: one involving external beam radiotherapy and the other using internal irradiation with an alpha-particle-emitting actinium-225 radiolabeled antibody. We compared the mean T2 values of different renal compartments between control and external beam radiotherapy or alpha-particle-emitting actinium-225 radiolabeled antibody-treated groups and between the two radiation-treated groups using a Wilcoxon rank-sum test. Results Significantly higher T-2 values were found in the cortex and outer stripe of the outer medulla in all treated animals compared with the control group (p < 0.05). In addition, these changes in T-2 were observed before any changes in serum parameters, animal body weight, and kidney volume occurred. Conclusion T-2 mapping is sensitive to radiation-induced tubulointerstitial changes in the kidney.

引用

页数：11

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