CFTR Prevents Type 2 Inflammation by Reducing IL-4 Signaling in Th2 Cells

被引:0
|
作者
Cook, D. P. [1 ]
Thomas, C. [1 ]
Hodges, C. [2 ]
Kerchberger, V. E. [3 ]
Newcomb, D. C. [4 ]
Stoltz, D. A. [5 ]
Peebles, R. [1 ]
机构
[1] Vanderbilt Univ, Internal Med, Med Ctr, Nashville, TN USA
[2] Case Western Reserve Univ, Genet & Genome Sci, Cleveland, OH USA
[3] Vanderbilt Univ, Div Allergy Pulm & Crit Care Med, Med Ctr, Nashville, TN USA
[4] Vanderbilt Univ, Internal Med, Nashville, TN USA
[5] Univ Iowa, Internal Med, Iowa City, IA USA
关键词
D O I
暂无
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
A6993
引用
收藏
页数:2
相关论文
共 50 条
  • [41] DISRUPTION OF THE MURINE IL-4 GENE BLOCKS TH2 CYTOKINE RESPONSES
    KOPF, M
    LEGROS, G
    BACHMANN, M
    LAMERS, MC
    BLUETHMANN, H
    KOHLER, G
    NATURE, 1993, 362 (6417) : 245 - 248
  • [42] Th2 Cytokines IL-4 and IL-13 Downregulate Paxillin Expression in Bronchial Airway Epithelial Cells
    Gail Ramirez-Icaza
    Kamal A. Mohammed
    Najmunnisa Nasreen
    Robert D. Van Horn
    Joyce A. Hardwick
    Kerry L. Sanders
    Jun Tian
    Carlos Ramirez-Icaza
    Mary T. Johnson
    Veena B. Antony
    Journal of Clinical Immunology, 2004, 24 : 426 - 434
  • [43] Tyrosine phosphorylation of c-Maf mediates the IL-4 gene expression in Th2 cells
    Miaw, Shi-Chuen
    Lai, Chen-Yen
    CYTOKINE, 2011, 56 (01) : 82 - 82
  • [44] Th2 cytokines IL-4 and IL-13 downregulate paxillin expression in bronchial airway epithelial cells
    Ramirez-Icaza, G
    Mohammed, KA
    Nasreen, N
    Van Horn, RD
    Hardwick, JA
    Sanders, KL
    Tian, J
    Ramirez-Icaza, C
    Johnson, MT
    Antony, VB
    JOURNAL OF CLINICAL IMMUNOLOGY, 2004, 24 (04) : 426 - 434
  • [45] IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement
    Schmidt-Weber, CB
    Alexander, SI
    Henault, LE
    James, L
    Lichtman, AH
    JOURNAL OF IMMUNOLOGY, 1999, 162 (01): : 238 - 244
  • [46] Priming for Th2 differentiation by IL-2-mediated induction of IL-4 receptor α chain expression
    Liao, Wei
    Schones, Dustin E.
    Oh, Jangsuk
    Cui, Yongzhi
    Cui, Kairong
    Roh, Tae-Young
    Zhao, Keji
    Leonard, Warren J.
    CYTOKINE, 2009, 48 (1-2) : 112 - 112
  • [47] IL-4 sensitivity and Th2 T cells in cystic fibrosis patients with allergic bronchopulmonary aspergillosis
    Knutsen, AP
    Hutcheson, PS
    Kurup, V
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 109 (01) : S343 - S343
  • [48] Autocrine IL-4 gene regulation at late phases of TCR activation in differentiated Th2 cells
    Dorado, B
    Jerez, MJ
    Flores, N
    Martín-Saavedra, FM
    Durán, C
    Ballester, S
    JOURNAL OF IMMUNOLOGY, 2002, 169 (06): : 3030 - 3037
  • [49] IL-4 and IL-13 induce eotaxin in dermal fibroblasts:: A possible mechanism of eosinophil recruitment in TH2 type cytokine mediated skin inflammation
    Mochizuki, M
    Bartels, J
    Christophers, E
    Schröder, JM
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 110 (04) : 501 - 501
  • [50] EFFECTS OF TH2 CYTOKINES IL-4 AND IL-13 ON LYMPHATIC VESSELS IN THE LUNG
    Sin, K. H.
    Rpkataru
    Lee, S. H.
    RESPIROLOGY, 2013, 18 : 20 - 20