This contribution presents bulk-rock geochemical data with Sr-Nd-Hf isotopes and LA-ICP-MS U-Pb zircon geochronology for volcanic rocks from the Slanske<acute accent> Vrchy Mountains (E-Slovakia), a c. 50 km long volcanic chain located at the western flank of the Miocene Transcarpathian Basin System. The studied volcanics are represented by calc-alkaline andesites and dacites. More mafic composition was only found in a basaltic andesite enclave. Robust concordant U-Pb zircon ages for andesites (n = 6) and dacites (n = 3) range from 12.3 Ma to 11.8 Ma, indicating quasi-contemporaneous post-collisional volcanism. The basaltic andesite, andesites, and dacites have overlapping and correlated isotopic compositions (87Sr/86Sr(12Ma) = 0.7071 to 0.7104, epsilon Nd(12Ma) = -7.0 to -1.0, and epsilon Hf(12 Ma) = -6.2 to +2.8), which reflect mantle-crust interaction. A general lack of clear correlations between fractionation indicator SiO2 and isotope ratios as well as overlapping isotopic compositions of the andesites and dacites preclude simple coupled assimilation fractional crystallization (AFC) processes. Furthermore, the overall paucity of inherited zircons indicates limited assimilation at upper crustal levels. Pyroxene geothermobarometry points to a complex transcrustal volcanic system, which most likely involved processes of mixing, assimilation, storage, and homogenization (MASH) in the lower crust. Initial melt generation in the mantle was probably triggered by mantle upwelling in a generally extensional tectonic regime, but details on the nature of the mantle source remain enigmatic.