Genetic Variations Affect Chemotherapy Outcomes: A Role of the Spindle-assembly Checkpoint

被引：1
|
作者：
Sarkar, Sinjini [1 ,2 ]
Pal, Ranita [1 ]
Choudhury, Trisha [1 ]
Vernekar, Manisha [3 ]
Nath, Partha [4 ]
Nasare, Vilas D. [1 ]
机构：
[1] Chittaranjan Natl Canc Inst, Dept Pathol & Canc Screening, 37 SP Mukherjee Rd, Kolkata 700026, W Bengal, India
[2] Jadavpur Univ, Dept Pharmaceut Technol, Kolkata, India
[3] Chittaranjan Natl Canc Inst, Dept Gynaecol Oncol, Gynaecol Oncol, Kolkata, India
[4] Chittaranjan Natl Canc Inst, Dept Med Oncol, Med Oncol, Kolkata, India
来源：
INDIAN JOURNAL OF PUBLIC HEALTH | 2024年 / 68卷 / 02期
关键词：
Budding Uninhibited by Benzimidazoles 3; carboplatin; ovarian cancer; paclitaxel; spindle-assembly checkpoint; CANCER;
D O I：
10.4103/ijph.ijph_809_23
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Cancer patients suffer from complicated chemotoxicity. Pharmacogenomics can help stratify patients by predicting their response to treatment and susceptibility toward severe side effects. The spindle-assembly checkpoint (SAC) is an important pathway that is activated by platinum and taxane compounds and plays a crucial role in their cytotoxic activity. This study investigated a SAC component, Budding Uninhibited by Benzimidazoles 3 (BUB3), its expression, and genetic variants in advanced ovarian cancer patients treated with paclitaxel-carboplatin chemotherapy. Among 80 patients, BUB3 expression correlated with chemosensitivity, suggesting its potential as a predictive marker for chemotherapy response. However, high BUB3 expression was associated with a higher risk of poor survival. In addition, genetic polymorphisms in BUB3 (rs11248416 and rs11248419) were significantly linked to chemotherapy-related toxicities, with rs11248416 showing a negative impact on the patient's physical quality of life.
引用
收藏
页码：314 / 317
页数：4
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