Hidradenitis Suppurativa: A Review of the Biologic and Small Molecule Immunomodulatory Treatments

被引:0
|
作者
Chiang, Nicholas [1 ]
Alhusayen, Raed [1 ,2 ]
机构
[1] Univ Toronto, Temerty Fac Med, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada
[2] Sunnybrook Hlth Sci Ctr, Dept Dermatol, Toronto, ON, Canada
关键词
hidradenitis suppurativa; biologic; immunomodulator; LONG-TERM EFFICACY; DOUBLE-BLIND; OPEN-LABEL; INFLIXIMAB; MODERATE; ETANERCEPT; ADALIMUMAB; SAFETY; CANAKINUMAB; MANAGEMENT;
D O I
10.1177/12034754241300292
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that presents as painful, deep-seated nodules, sinus tracts, and abscesses in about 1% of the population. Although the pathogenesis of HS is not perfectly understood, it is generally recognized to be caused by a combination of genetic, endocrine, environmental, and microbiological factors. The treatment principles of HS focus on decreasing the microbial load with antibiotics and/or modulating the host immune response to reduce inflammation. The treatment of adults with moderate-to-severe HS has significantly changed recently with the development of new biological medications and immunomodulators. While previously the mainstay of treatment of moderate-to-severe HS was adalimumab, a biologic tumour necrosis factor alpha inhibitor, the evidence for the use of other treatment classes such as interleukin (IL)-17 inhibitors, IL-1 inhibitors, and Janus kinase inhibitors has been growing. The goal of this review article is to review the available evidence that supports the efficacy and safety of biologics and small molecule immunomodulator treatments to treat adults with moderate-to-severe HS.
引用
收藏
页码:NP1 / NP20
页数:20
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