Cyclization of sulfoxonium ylides with 2-aminopyridines towards imidazo [1,2-a]pyridines

被引：0
|
作者：
Luu, Vu H. [1 ,2 ]
Trinh, Hoang V. M. [1 ,2 ]
Tran, Dat H. [1 ,2 ]
Le, Tuong Q. [1 ,2 ]
Nguyen, Tung T. [1 ,2 ]
机构：
[1] Ho Chi Minh City Univ Technol HCMUT, VNU HCM Key Lab Struct Adv Mat, 268 Ly Thuong Kiet,Dist 10, Ho Chi Minh City, Vietnam
[2] Vietnam Natl Univ Ho Chi Minh City, Ho Chi Minh City, Vietnam
来源：
TETRAHEDRON LETTERS | 2025年 / 156卷
关键词：
Sulfoxonium ylides; Imidazo[1; a ]pyridines; Lewis acid catalyst; C-H AMINATION; CATALYST; FACILE;
D O I：
10.1016/j.tetlet.2024.155438
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for cyclization of 2-aminopyridines and sulfoxonium ylides is developed. The approach would avoid the requirement of pre-functionalized, Ortoleva-King typed alpha-haloketones for such cyclization. The annulation was facilitated in the presence of nickel(II) bromide, presumably as the Lewis acid catalyst. An array of functionalities including secondary amine, nitro, and halogen groups were tolerated. Two examples of alkyl sulfoxonium ylides were also presented. Our method feature a new approach to afford synthetically useful C 2substituted imidazo[1,2-a]pyridines from derivatives of benzoic acids.
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页数：3
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