The major biogenic amine metabolites in mood disorders

被引：0
|
作者：
Yang, Jingyi [1 ]
Yuan, Minlan [1 ]
Zhang, Wei [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, West China Hosp, Mental Hlth Ctr, Psychiat Lab,State Key Lab Biotherapy, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp, West China Biomed Big Data Ctr, Chengdu, Peoples R China
[3] Sichuan Univ, Big Data Ctr, Chengdu, Peoples R China
来源：
FRONTIERS IN PSYCHIATRY | 2024年 / 15卷
关键词：
mood disorder; major depressive disorder; bipolar disorder; metabolite; biogenic amine; HISTAMINE H-3 RECEPTOR; CREATINE MONOHYDRATE AUGMENTATION; KYNURENINE PATHWAY METABOLITES; DEPRESSIVE-LIKE BEHAVIORS; BIPOLAR DISORDER; GUT MICROBIOTA; DOUBLE-BLIND; ADOLESCENT DEPRESSION; NEUROTROPHIC FACTOR; FEMALE ADOLESCENTS;
D O I：
10.3389/fpsyt.2024.1460631
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Mood disorders, including major depressive disorder and bipolar disorder, have a profound impact on more than 300 million people worldwide. It has been demonstrated mood disorders were closely associated with deviations in biogenic amine metabolites, which are involved in numerous critical physiological processes. The peripheral and central alteration of biogenic amine metabolites in patients may be one of the potential pathogeneses of mood disorders. This review provides a concise overview of the latest research on biogenic amine metabolites in mood disorders, such as histamine, kynurenine, and creatine. Further studies need larger sample sizes and multi-center collaboration. Investigating the changes of biogenic amine metabolites in mood disorders can provide biological foundation for diagnosis, offer guidance for more potent treatments, and aid in elucidating the biological mechanisms underlying mood disorders.
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页数：14
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