Water-Soluble Aromatic Nanobelt with Unique Cellular Internalization

被引：0

作者：

Gunther, Konstantin ^{[1
,2
]}

Kono, Hideya ^{[1
]}

Shudo, Hiroki ^{[1
]}

Shimizu, Daisuke ^{[1
]}

Isoda, Reika ^{[3
]}

Nakamura, Masayoshi ^{[3
]}

Yagi, Akiko ^{[1
,3
]}

Amaike, Kazuma ^{[4
]}

Itami, Kenichiro ^{[3
,4
]}

机构：

[1] Nagoya Univ, Grad Sch Sci, Dept Chem, Nagoya, Aichi 4648602, Japan

[2] Humboldt Univ, Dept Chem, Brook Taylor Str 2, D-12489 Berlin, Germany

[3] Nagoya Univ, Inst Transformat Biomol WPI ITbM, Nagoya, Aichi 4648602, Japan

[4] RIKEN, RIKEN Cluster Pioneering Res, Mol Creat Lab, Wako, Saitama 3510198, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2025年 / 64卷 / 07期

关键词：

aromatic compounds; bioimaging; cycloparaphenylene; late-stage functionalization; nanobelt; CARBON; NANOHOOPS;

D O I：

10.1002/anie.202414645

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A water-soluble aromatic nanobelt was synthesized, and its cellular uptake behavior in HeLa cells was investigated. The late-stage functionalization of the parent methylene-bridged [6]cycloparaphenylene ([6]MCPP) provided an easily accessible alkyne-functionalized nanobelt in a single reaction step. The alkyne-substituted [6]MCPP was subjected to Cu-catalyzed azide-alkyne cycloaddition by using a dye-attached azide to obtain a water-soluble aromatic nanobelt. Cell-imaging experiments on the synthesized nanobelt in HeLa cells revealed stop-and-go cellular uptake dynamics. Similar experiments with control molecules and theoretical studies indicated that the unique dynamics of the nanobelt was derived from the belt-shaped structure.

引用

页数：5

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