Therapeutic Potential of Prenylated Flavonoids of the Fabaceae Family in Medicinal Chemistry: An Updated Review

被引:1
|
作者
Morante-Carriel, Jaime [1 ,2 ]
Najera, Hugo [1 ,3 ]
Samper-Herrero, Antonio [1 ,4 ]
Zivkovic, Suzana [5 ]
Martinez-Esteso, Maria Jose [1 ,4 ]
Martinez-Marquez, Ascension [1 ,4 ]
Selles-Marchart, Susana [1 ,6 ]
Obrebska, Anna [1 ]
Bru-Martinez, Roque [1 ,4 ,7 ]
机构
[1] Univ Alicante, Fac Sci, Dept Biochem & Mol Biol & Soil & Agr Chem, Plant Prote & Funct Genom Grp, Carretera San Vicente del Raspeig S-N, Alicante 03690, Spain
[2] Quevedo State Tech Univ, Fac Forestry & Agr Sci, Plant Biotechnol Grp, Ave Quito Km 1 1-2 Via Santo Domingo Tsachilas, Quevedo 120501, Ecuador
[3] Univ Autonoma Metropolitana Cuajimalpa, Dept Ciencias Nat, Ave Vasco de Quiroga 4871, Ciudad De Mexico 05348, Mexico
[4] Alicante Inst Hlth & Biomed Res ISABIAL, Alicante 03010, Spain
[5] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, Bulevar Despota Stefana 142, Belgrade 11108, Serbia
[6] Univ Alicante, Prote & Genom Div, Res Tech Facil, Alicante 03690, Spain
[7] Univ Alicante, Multidisciplinary Inst Study Environm IMEM, Alicante 03690, Spain
关键词
prenytaled flavonoids; natural compounds; bioactivity; Fabaceae; medicinal plants; PSORALEA-CORYLIFOLIA; INHIBITORY-ACTIVITY; SOPHORAFLAVANONE-G; PPAR-GAMMA; DERIVATIVES; CHALCONES; CELLS; ISOFLAVONES; FLAVANONES; EXTRACT;
D O I
10.3390/ijms252313036
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Much attention has been paid to the potential biological activities of prenylated flavonoids (PFs) in various plant families over the last decade. They have enormous potential for biological activities, such as anti-cancer, anti-diabetic, antimicrobial, anti-inflammatory, anti-Alzheimer's, and neuroprotective activities. Medicinal chemists have recently shown a strong interest in PFs, as they are critical to the development of new medicines. PFs have been rapidly prepared by isolation and semi- or full synthesis, demonstrating their significant utility in medicinal chemistry research. This study encompasses the research progress on PFs in the last decade, including their pharmacological activities in the Fabaceae family. This information demonstrates the bioactive potential of PF compounds and their role in the control and treatment of various human health problems.
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页数:37
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