Therapeutic Potential of Prenylated Flavonoids of the Fabaceae Family in Medicinal Chemistry: An Updated Review

被引:1
|
作者
Morante-Carriel, Jaime [1 ,2 ]
Najera, Hugo [1 ,3 ]
Samper-Herrero, Antonio [1 ,4 ]
Zivkovic, Suzana [5 ]
Martinez-Esteso, Maria Jose [1 ,4 ]
Martinez-Marquez, Ascension [1 ,4 ]
Selles-Marchart, Susana [1 ,6 ]
Obrebska, Anna [1 ]
Bru-Martinez, Roque [1 ,4 ,7 ]
机构
[1] Univ Alicante, Fac Sci, Dept Biochem & Mol Biol & Soil & Agr Chem, Plant Prote & Funct Genom Grp, Carretera San Vicente del Raspeig S-N, Alicante 03690, Spain
[2] Quevedo State Tech Univ, Fac Forestry & Agr Sci, Plant Biotechnol Grp, Ave Quito Km 1 1-2 Via Santo Domingo Tsachilas, Quevedo 120501, Ecuador
[3] Univ Autonoma Metropolitana Cuajimalpa, Dept Ciencias Nat, Ave Vasco de Quiroga 4871, Ciudad De Mexico 05348, Mexico
[4] Alicante Inst Hlth & Biomed Res ISABIAL, Alicante 03010, Spain
[5] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, Bulevar Despota Stefana 142, Belgrade 11108, Serbia
[6] Univ Alicante, Prote & Genom Div, Res Tech Facil, Alicante 03690, Spain
[7] Univ Alicante, Multidisciplinary Inst Study Environm IMEM, Alicante 03690, Spain
关键词
prenytaled flavonoids; natural compounds; bioactivity; Fabaceae; medicinal plants; PSORALEA-CORYLIFOLIA; INHIBITORY-ACTIVITY; SOPHORAFLAVANONE-G; PPAR-GAMMA; DERIVATIVES; CHALCONES; CELLS; ISOFLAVONES; FLAVANONES; EXTRACT;
D O I
10.3390/ijms252313036
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Much attention has been paid to the potential biological activities of prenylated flavonoids (PFs) in various plant families over the last decade. They have enormous potential for biological activities, such as anti-cancer, anti-diabetic, antimicrobial, anti-inflammatory, anti-Alzheimer's, and neuroprotective activities. Medicinal chemists have recently shown a strong interest in PFs, as they are critical to the development of new medicines. PFs have been rapidly prepared by isolation and semi- or full synthesis, demonstrating their significant utility in medicinal chemistry research. This study encompasses the research progress on PFs in the last decade, including their pharmacological activities in the Fabaceae family. This information demonstrates the bioactive potential of PF compounds and their role in the control and treatment of various human health problems.
引用
收藏
页数:37
相关论文
共 50 条
  • [1] Medicinal Uses of the Fabaceae Family in Zimbabwe: A Review
    Maroyi, Alfred
    PLANTS-BASEL, 2023, 12 (06):
  • [2] Prenylated Flavonoids of the Moraceae Family: A Comprehensive Review of Their Biological Activities
    Morante-Carriel, Jaime
    Zivkovic, Suzana
    Najera, Hugo
    Selles-Marchart, Susana
    Martinez-Marquez, Ascension
    Martinez-Esteso, Maria Jose
    Obrebska, Anna
    Samper-Herrero, Antonio
    Bru-Martinez, Roque
    PLANTS-BASEL, 2024, 13 (09):
  • [3] Therapeutic potential of curcumin in medicinal chemistry
    Kost'alova, Daniela
    Bezakova, Lydia
    Rackova, Lucia
    Mosovska, Silvia
    Sturdik, Ernest
    ACTA CHIMICA SLOVACA, 2013, 6 (01): : 89 - 99
  • [4] Medicinal and biological potential of pumpkin: an updated review
    Yadav, Mukesh
    Jain, Shalini
    Tomar, Radha
    Prasad, G. B. K. S.
    Yadav, Hariom
    NUTRITION RESEARCH REVIEWS, 2010, 23 (02) : 184 - 190
  • [5] Medicinal chemistry and therapeutic potential of CpG DNA
    Agrawal, S
    Kandimalla, ER
    TRENDS IN MOLECULAR MEDICINE, 2002, 8 (03) : 114 - 121
  • [6] Citrus flavonoids as potential therapeutic agents: A review
    Alam, Fiaz
    Mohammadin, Kinza
    Shafique, Zainab
    Amjad, Sayyeda Tayyeba
    bin Asad, Mohammad Hassham Hassan
    PHYTOTHERAPY RESEARCH, 2022, 36 (04) : 1417 - 1441
  • [7] Orexin receptor antagonists: Medicinal chemistry and therapeutic potential
    Roecker, Anthony J.
    Coleman, Paul J.
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2008, 8 (11) : 977 - 987
  • [8] Exploring the therapeutic potential of phenothiazine derivatives in medicinal chemistry
    Babalola, Benjamin A.
    Malik, Monika
    Sharma, Lekhnath
    Olowokere, Olanike
    Folajimi, Oreoluwa
    RESULTS IN CHEMISTRY, 2024, 8
  • [9] PRESENT SCENARIO OF HEPATOPROTECTIVE POTENTIAL OF MEDICINAL PLANTS: AN UPDATED REVIEW
    Saiju, Payal
    Jain, Priya
    Chatterjee, D. P.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2020, 11 (09): : 4189 - 4200
  • [10] The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators
    Lang, Alisa
    Isigkeit, Laura
    Schubert-Zsilavecz, Manfred
    Merk, Daniel
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (23) : 16956 - 16973