Palumoids A and B, Two New Dimeric Phenylpropanoids With Anti-gouty Activity From Erythropalum scandens Blume

被引:0
|
作者
Wei, Xia [1 ,2 ]
Dou, Bo-Qiang [1 ,2 ]
Zhang, Cai-Neng [2 ]
Su, Xun [2 ]
Ouyang, Wan-Qiong [2 ]
Shi, Zhimian [2 ]
Yang, Ying-Zhu [2 ,3 ]
Wang, De-Bao [2 ,3 ]
Gao, De-Feng [2 ]
Su, Jun-Cheng [2 ]
机构
[1] Guangxi Med Univ, Sch Pharm, Guangxi Key Lab Bioact Mol Res & Evaluat, Nanning, Peoples R China
[2] Guangxi Normal Univ, Collaborat Innovat Ctr Guangxi Ethn Med, State Key Lab Chem & Mol Engn Med Resources, Sch Chem & Pharmaceut Sci,Key Lab Chem & Mol Engn, Guilin, Peoples R China
[3] Guangxi Guize Biotechnol Co LTD, Tech Dept, Nanning, Peoples R China
基金
中国国家自然科学基金;
关键词
anti-gouty activity; <italic>Erythropalum scandens</italic> Blume; phenylpropanoid dimers; MANAGEMENT;
D O I
10.1002/cbdv.202403116
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Erythropalum scandens Blume is widely utilized as both a functional vegetable and herbal medicine in southern China, however, its bioactive components have yet to be fully identified. In this study, two new phenylpropanoid dimers palumoids A (1) and B (2) with distinct coupling manners were identified from the plant. Biologically, these phenylpropanoids showed superior inhibition of interleukin-1 beta release in monosodium urate-stimulated THP-1 cells compared to the positive drug colchicine. Notably, compound 2, featuring a pyran ring linkage between the two phenylpropanoid monomers, exhibited stronger activity than 1. Further mechanistic studies revealed that compound 2 acts as an NLRP3 inflammasome inhibitor by specifically blocking the activation of NLRP3, interfering with the assembly of the NLRP3 inflammasome complex.
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页数:7
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