Synthesis, Crystal Structure, Antibacterial and Antituberculosis Activities of Novel Thieno[2,3-b] [1,4] dithiine-1,1-dioxide Derivatives

被引：0

作者：

El-Abadelah, Mustafa M. ^{[1
]}

Al Ma'aiteh, Ata'a alhadi T. A. ^{[2
]}

Al-Soud, Yaseen A. ^{[2
]}

Zahraa, Jalal A. ^{[1
]}

Khanfar, Monther A. ^{[1
,3
]}

Al Saoud, Hussam A. ^{[4
]}

van Geelen, Lasse ^{[5
]}

Kalscheuer, Rainer ^{[5
]}

Stark, Holger ^{[6
]}

机构：

[1] Univ Jordan, Fac Sci, Chem Dept, Amman, Jordan

[2] Al al Bayt Univ, Fac Sci, Chem Dept, Al Mafraq, Jordan

[3] Univ Sharjah, Coll Sci, Dept Chem, Pure & Appl Chem Grp, Sharjah 2727, U Arab Emirates

[4] Jadara Univ, Fac Pharm, Irbid 21110, Jordan

[5] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Fac Math & Nat Sci, D-40225 Dusseldorf, Germany

[6] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut & Med Chem, Fac Math & Nat Sci, Univ str 1, D-40225 Dusseldorf, Germany

来源：

JORDAN JOURNAL OF CHEMISTRY | 2025年 / 20卷 / 01期

关键词：

Synthesis; thieno[2; 3-b] [1; 4; dithiine-1; 1-dioxide; antibacterial activity;

D O I：

10.47014/20.1.3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new thieno[2,3-b][1,4]dithiine-1,1-dioxide was prepared via intramolecular cycloaddition reaction between methyl (3-sulfonyl ester of thiophene and carbon disulfide (CS2) or ethoxycabonyl isothiocyanate. A new compound methyl 2-((2,5-dichlorothiophen-3yl)sulfonyl) acetate as methyl (3-sulfonyl ester was prepared via interaction between methyl 2bromoacetate and sodium 2,5-dichlorothiophene-3-sulfinate, which utilized in the cycloaddition reactions. Compounds 17 and 19b were tested for their antibacterial activity against Staphylococcus aureus and Escherichia coli. Additionally, 17 and 19b were assessed for their antibacterial activity against Mycobacterium tuberculosis strain mc26230. The tested compounds have shown insignificant activities toward the tested bacteria (minimal inhibitory concentration > 100 mu M).

引用

页码：27 / 39

页数：13

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