Two new compounds from the capitula of Chrysanthemum morifolium cv. Fubaiju

被引：0
|
作者：
Chen, Jin-Lin [1 ]
Huang, Yue-Hao [1 ]
Yang, Si-Yu [2 ]
Zhuo, Xue-Fang [1 ]
Li, Yao-Lan [1 ]
Zhang, Yu-Bo [2 ]
Zhong, Jun-Jie [3 ]
Wang, Guo-Cai [1 ]
机构：
[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Peoples R China
[2] Jinan Univ, Guangdong Clin Translat Ctr Targeted Drug, Sch Med, Dept Pharmacol, Guangzhou, Peoples R China
[3] Jinan Univ, Affiliated Hosp 1, Dept Pharm, Guangzhou, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2024年
基金：
中国国家自然科学基金;
关键词：
Chrysanthemum morifolium cv. Fubaiju; germacrane-type sesquiterpene; alkamide; antitumor activity; anti-RSV activity; SESQUITERPENOIDS; CONSTITUENTS;
D O I：
10.1080/14786419.2024.2409981
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new germacrane-type sesquiterpenoid (1) and a new alkamide (2), as well as six known compounds (3-8) were isolated from the capitula of Chrysanthemum morifolium cv. Fubaiju. The new structures were elucidated by comprehensive spectroscopic analysis and quantum chemical calculations. The known structures were characterised via 1D NMR data compared with the already existing literature data. Among the isolates, compound 5 showed inhibitory activity against human lung cancer A549 cells and human hepatoma HepG2 cells with the IC50 values of 19.50 +/- 1.23 and 23.24 +/- 1.30 mu M, respectively, and compound 8 exhibited inhibitory effect on RSV infection with IC50 value of 12.50 +/- 1.02 mu M. [GRAPHICS] .
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页数：7
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