Natural and Bioengineered Extracellular Vesicles in Diagnosis, Monitoring and Treatment of Cancer

被引：0
|
作者：
Luo, Xin [1 ,2 ]
Mcandrews, Kathleen M. [1 ]
Kalluri, Raghu [1 ,2 ,3 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77054 USA
[2] Rice Univ, Dept Bioengn, Houston, TX 77005 USA
[3] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
来源：
ACS NANO | 2025年 / 19卷 / 06期
关键词：
Extracellular vesicles(EVs); cancer; diagnosis; monitoring; tumor microenvironment (TME); immunemicroenvironment; cancer immunotherapy; drug delivery; cargo loading methods; large scale production; MESENCHYMAL STEM-CELLS; EXOSOME-MEDIATED DELIVERY; PROMOTE TUMOR-GROWTH; CO-DELIVERY; THERAPY; RNA; IMMUNOTHERAPY; NANOPARTICLES; PROLIFERATION; MACROPHAGES;
D O I：
10.1021/acsnano.4c11630
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Extracellular vesicles (EVs) are cell derived nanovesicles which are implicated in both physiological and pathological intercellular communication, including the initiation, progression, and metastasis of cancer. The exchange of biomolecules between stromal cells and cancer cells via EVs can provide a window to monitor cancer development in real time for better diagnostic and interventional strategies. In addition, the process of secretion and internalization of EVs by stromal and cancer cells in the tumor microenvironment (TME) can be exploited for delivering therapeutics. EVs have the potential to provide a targeted, biocompatible, and efficient delivery platform for the treatment of cancer and other diseases. Natural as well as engineered EVs as nanomedicine have immense potential for disease intervention. Here, we provide an overview of current knowledge of EVs' function in cancer progression, diagnostic and therapeutic applications for EVs in the cancer setting, as well as current EV engineering strategies.
引用
收藏
页码：5871 / 5896
页数：26
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