Urazoles as Heterocyclic Directing Groups in Ru(II)-Catalyzed Annulation of N-H/C-H Bonds with Vinylene Carbonate

被引：1

作者：

Kang, Jungmin ^{[1
]}

Park, Jihye ^{[1
]}

Singh, Pargat ^{[1
]}

Jeong, Taejoo ^{[1
]}

Kim, In Su ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年

基金：

新加坡国家研究基金会;

关键词：

BIOCONJUGATION; ACTIVATION; INHIBITORS; TYROSINE;

D O I：

10.1021/acs.joc.4c02033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of novel directing groups is a valuable strategy to secure the advancement of catalytic C-H functionalization. To illustrate the feasibility of urazoles as heterocyclic directing groups, we herein present the ruthenium(II)-catalyzed annulation of N-H/C-H bonds on N-aryl urazoles with vinylene carbonate. This transformation provides the rapid construction of triazolocinnoline derivatives as hemiaminal and dehydrated forms. A series of mechanistic investigations and post-transformations highlighted the amenability of the developed method.

引用

页数：11

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