The heterodimer of 2-amino-1,8-naphthyridine and 3-aminoisoquinoline binds to the CTG/CTG triad via hydrogen bonding

被引：0
|
作者：
Sakurabayashi, Shuhei [1 ]
Yamada, Takeshi [1 ]
Nakatani, Kazuhiko [1 ]
机构：
[1] Osaka Univ, Inst Sci & Ind Res SANKEN, Dept Regulatory Bioorgan Chem, 8-1 Mihogaoka, Ibaraki 5670047, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2024年 / 114卷
关键词：
Small molecule ligand; Mismatched base pair; CTG repeat; Nuclear Magnetic Resonance (NMR); MYOTONIC-DYSTROPHY; REPEAT; EXPANSION; REGION;
D O I：
10.1016/j.bmcl.2024.129985
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Myotonic dystrophy type 1 (DM1) is caused by the aberrant expansion of CTG repeats within the DMPK gene. This study investigated the potential binding of "X-linker-Y" type molecules to the CTG/CTG motif present in CTG repeats, using heterocyclic units X and Y capable of forming complementary hydrogen bonds with nucleobases. Among the tested molecules, the heterodimer of 2-amino-1,8-naphthyridine (X) and 3-aminoisoquinoline (Y) showed significant binding to the CTG/CTG motif. NMR analysis suggested hydrogen-bonded interactions between 3-aminoisoquinoline and thymine.
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页数：5
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