Water-soluble 2-amino-1,8-naphthyridine as a novel DNA binding photosensitizer for one-electron oxidation of DNA

被引：4
|
作者：
Nakatani, K [1 ]
Sando, S [1 ]
Yoshida, K [1 ]
Saito, I [1 ]
机构：
[1] Kyoto Univ, Fac Engn, Dept Synth Chem & Biol Chem, CREST, Kyoto 6068501, Japan
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 33期
关键词：
D O I：
10.1016/S0040-4039(99)01189-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
DNA binding and photoinduced DNA cleaving properties of water-soluble naphthyridine derivative 1 were investigated. The photoinduced cleavage of DNA was studied by both PAGE and product analysis, indicating that the DNA cleavage proceeds via one-electron oxidation pathway. (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码：6029 / 6032
页数：4
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