Concomitant (3+3) Annulation/Fragmentation of Triazinanes with Enamines: Electrosynthesis of Multisubstituted Dihydropyrimidines

被引：0
|
作者：
Dutta, Jhilik [1 ]
Ghosh, Sayan [1 ]
Hassan, Aaliya [1 ]
De Sarkar, Suman [1 ]
机构：
[1] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741246, West Bengal, India
来源：
ORGANIC LETTERS | 2025年 / 27卷 / 11期
关键词：
ACCESS;
D O I：
10.1021/acs.orglett.5c00418
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An electro-oxidative formal (3 + 3) annulation of 1,3,5-triazinanes with enamines toward multisubstituted 1,2-dihydropyrimidines is reported. This metal-free mild protocol offers wide functional group tolerance, and heterocycles with an unexplored molecular scaffold were constructed in excellent yields. Mechanistically, the electro-oxidation of triazinane and nucleophilic reactivity of enamine result in a concomitant annulation-fragmentation process, leading to the six-membered heterocyclic product.
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收藏
页码：2682 / 2686
页数：5
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