Synthesis of Thiochromans via [3+3] Annulation of Aminocyclopropanes with Thiophenols

被引：9
|
作者：
Wang, Ming-Ming [1 ]
Jeon, Seongmin [1 ]
Waser, Jerome [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, Lab Catalysis & Organ Synth, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 22期
基金：
瑞士国家科学基金会;
关键词：
D O I：
10.1021/acs.orglett.0c03528
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report the one-pot synthesis of 4-amino thiochromans using simple aminocyclopropanes and thiophenols through a formal [3+3] annulation reaction. This reaction proceeds under mild conditions with good functional group tolerance. The thiochroman core was formed with complete regioselectivity, and modification of complex drug molecules containing an aminocyclopropane was also realized.
引用
收藏
页码：9123 / 9127
页数：5
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