Different metal salts catalyzed alkylation or cycloaddition of indolylquinones with diethyl malonate via base-mediated

被引：0

作者：

Dong, Yu ^{[1
]}

Wu, Chun-Mei ^{[1
]}

Xie, Li ^{[2
]}

Yu, Jing-Hao ^{[1
]}

Wang, Zhi-Fan ^{[1
]}

Shi, Zhi-Chuan ^{[3
]}

Deng, Guo-Wei ^{[1
]}

He, Bing ^{[1
]}

机构：

[1] Chengdu Normal Univ, Coll Chem & Life Sci, Sichuan Prov Key Lab Struct Optimizat & Applicat, Chengdu 611130, Peoples R China

[2] Chengdu Inst Drug Control, Chengdu 611130, Peoples R China

[3] Southwest Minzu Univ, Chengdu 610041, Peoples R China

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2025年 / 1329卷

关键词：

Base-mediated; Alkylation; Cycloaddition; Indolylquinones; Diethyl malonate; ACUTE MYELOID-LEUKEMIA; C-H ALKYLATION; QUINONES; 1,4-QUINONES; CALOTHRIXINS; MIDOSTAURIN; PARVAQUONE; ACTIVATION; PARASITES; RADICALS;

D O I：

10.1016/j.molstruc.2024.141286

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Different metal salts catalyzed alkylation or cycloaddition of indolylquinones with diethyl malonate via base- mediated have been developed. Due to differences in alkalinity and metal coordination, copper catalysis and zinc catalysis exclusively afforded selective products. This reaction offers an approach to generating the alkylated indolylquinones and polycyclic quinones N-heterocycles in 57- 89 % yields.

引用

页数：11