Scalable, High-Titer Production of Clinical Grade Adeno Associated Virus in the Gibco™ CTS™ AAV-MAX Helper-Free AAV Production System

被引：0
|
作者：
Liu, Chao Yan [1 ]
Thompson, Kenneth W. [1 ]
Decaria, Paula [2 ]
Williston, Kyle [1 ]
Rasmussen, Collin [1 ]
Weinkauf, Mariah [1 ]
Miller, Natalie [1 ]
Jackson-Holmes, Emily [3 ]
Zmuda, Jonathan [1 ]
机构：
[1] Thermo Fisher Sci, Frederick, MD USA
[2] Thermo Fisher Sci, Logan, UT USA
[3] Thermo Fisher Sci, Carlsbad, CA USA
来源：
MOLECULAR THERAPY | 2024年 / 32卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
1502
引用
收藏
页码：707 / 707
页数：1
相关论文
共 37 条
  • [31] The ELEVECTA® HEK293 Platform - An Innovative, Fully Stable and Helper Virus-Free AAV Production System
    Hoelper, Julia E.
    Hudjetz, Ben
    Schmidt-Hertel, Sabine
    Grabeck, Tamara
    Bergmann, Annika
    Srinivasan, Keerthana
    Al-Dali, Ahmad
    Coronel, Juliana
    Strempel, Nikola
    Hein, Kerstin
    Faust, Nicole
    MOLECULAR THERAPY, 2022, 30 (04) : 350 - 351
  • [32] Optimised helper virus-free production of high-quality adeno-associated virus vectors
    Drittanti, L
    Jenny, C
    Poulard, K
    Samba, A
    Manceau, P
    Soria, N
    Vincent, N
    Danos, O
    Vega, M
    JOURNAL OF GENE MEDICINE, 2001, 3 (01): : 59 - 71
  • [33] An autonucleolytic suspension HEK293F host cell line for high-titer serum-free AAV5 and AAV9 production with reduced levels of DNA impurity
    Howe, Geoffrey
    Bal, Mehtap
    Wasmuth, Matt
    Massaro, Giulia
    Rahim, Ahad A.
    Ali, Sadfer
    Rivera, Milena
    Schofield, Desmond M.
    Omotosho, Aminat
    Ward, John
    Keshavarz-Moore, Eli
    Mason, Chris
    Nesbeth, Darren N.
    MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT, 2024, 32 (03)
  • [34] Establishment of a Scalable Production Process Using Stable Helper-Virus Free AAV Producer Cell Lines Based on Human Suspension Cells
    Hein, Kerstin
    Goncalves, Ines do Carmo
    Strempel, Nikola
    Woelfel, Jens
    Niehus, Christian
    Hudjetz, Ben
    Riebesehl, Nina
    Kewes, Helmut
    Bauer, Thu
    Jamaladin, Israa
    Patil, Aishwarya
    Al-Dali, Ahmad
    Bialek, Corinna
    Coronel, Juliana
    Wissing, Silke
    Faust, Nicole
    MOLECULAR THERAPY, 2020, 28 (04) : 204 - 205
  • [35] Process Development for the Production and Purification of Adeno-Associated Virus (AAV)2 Vector using Baculovirus-Insect Cell Culture System
    Nasimuzzaman, Md
    Villaveces, Sophia
    van der Loo, Johannes C. M.
    Alla, Sivani
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2022, (179):
  • [36] Development of a Stable Helper Virus-Free Producer Cell Line for Scalable Adeno-Associated Virus Vectors Production Based on Human Suspension Cells
    Goncalves, Ines do Carmo
    Hein, Kerstin
    Hudjetz, Ben
    Strempel, Nikola
    Riebesehl, Nina
    Kewes, Helmut
    Bauer, Thu
    Jamaladin, Israa
    Bialek, Corinna
    Schmidt-Hertel, Sabine
    Coronel, Juliana
    Patil, Aishwarya
    Al-Dali, Ahmad
    Faust, Nicole
    Wissing, Silke
    MOLECULAR THERAPY, 2020, 28 (04) : 201 - 202
  • [37] Enhancing the production of adeno-associated virus (AAV)2 and AAV9 with high full capsid ratio in HEK293 cells through design-of-experiment optimization of triple plasmid ratio
    Park, Sungje
    Shin, Seunghyeon
    Lee, Haeshin
    Jang, Jae-Hyung
    Lee, Gyun Min
    BIOTECHNOLOGY JOURNAL, 2024, 19 (03)
1234