Advances in Artificially Designed Antibacterial Active Antimicrobial Peptides

被引：0

作者：

Guo, Ying ^{[1
,2
]}

Farhan, Muhammad Haris Raza ^{[3
]}

Gan, Fei ^{[4
,5
]}

Yang, Xiaohan ^{[3
]}

Li, Yuxin ^{[1
,2
]}

Huang, Lingli ^{[1
,2
,3
]}

Wang, Xu ^{[1
,2
,3
]}

Cheng, Guyue ^{[1
,2
,3
]}

机构：

[1] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan, Hubei, Peoples R China

[2] Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan, Hubei, Peoples R China

[3] Huazhong Agr Univ, MOA Lab Risk Assessment Qual & Safety Livestock &, Wuhan, Hubei, Peoples R China

[4] Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan, Peoples R China

[5] Wuhan Univ, TaiKang Ctr Life & Med Sci, Wuhan, Peoples R China

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 2024年

基金：

中国国家自然科学基金;

关键词：

antimicrobial peptides; artificial designing; drug resistance; machine learning; peptides database; synthetic peptides; SYNTHETIC BIOLOGY; EXPRESSION; MECHANISM; NANOPARTICLES; PURIFICATION; BACTERIOCIN; VANCOMYCIN; ANALOGS;

D O I：

10.1002/bit.28886

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Antibacterial resistance has emerged as a significant global concern, necessitating the urgent development of new antibacterial drugs. Antimicrobial peptides (AMPs) are naturally occurring peptides found in various organisms. Coupled with a wide range of antibacterial activity, AMPs are less likely to develop drug resistance and can act as potential agents for treating bacterial infections. However, their characteristics, such as low activity, instability, and toxicity, hinder their clinical application. Consequently, researchers are inclined towards artificial design and optimization based on natural AMPs. This review discusses the research advancements in the field of artificial designing and optimization of various AMPs. Moreover, it highlights various strategies for designing such peptides, aiming to provide valuable insights for developing novel AMPs.

引用

页数：18

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