Neutralizing Antibody Responses to Chlamydia trachomatis in Women and Associations With Chlamydia Outcomes

被引：1

作者：

Yu, Hong ^{[1
]}

Geisler, William M. ^{[2
]}

Dai, Chuanbin ^{[1
]}

Gupta, Kanupriya ^{[2
]}

Cutter, Gary ^{[3
]}

Brunham, Robert C. ^{[1
]}

机构：

[1] Univ British Columbia, British Columbia Ctr Dis Control, Vancouver, BC, Canada

[2] Univ Alabama Birmingham, Dept Med, Birmingham, AL USA

[3] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2024年

基金：

美国国家卫生研究院;

关键词：

chlamydia infection; clinical outcomes; neutralizing antibody; serology; women; INFECTION; IMMUNITY; PROTECTION;

D O I：

10.1093/infdis/jiae519

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed neutralizing antibody responses in a well-characterized cohort of 60 women with different Chlamydia trachomatis infection outcomes noted at a treatment visit and 3-month follow-up. We found varying rates of neutralization (inhibition of C trachomatis) in sera at different dilution levels and varying neutralizing antibody titers across outcomes. Median neutralization rates were significantly higher in sera at high dilutions (1:320-1:1280) from women with spontaneous resolution vs persisting infection before treatment (all P < .05). These findings suggest that neutralizing antibody responses may contribute to protective immunity against chlamydia.

引用

页数：5

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