Outer Retinal Tubulation and Vision in Geographic Atrophy: A Natural History Analysis From the Phase 3 OAKS and DERBY Trials

BACKGROUND AND OBJECTIVE: Outer retinal lation (ORT) is an optical coherence tomography finding in numerous chronic retinal diseases, cluding geographic atrophy (GA). The objective this study was to evaluate longitudinal best-corrected visual acuity (BCVA) outcomes in patients with GA comparing eyes with and without ORT baseline. PATIENTS AND METHODS: This post hoc longitudinal analysis assessed 300 eyes randomized to treatment in the phase 3 OAKS and DERBY trials. Mean change in BCVA over 24 months was calculated, comparing lesions with ORT versus without ORT at baseline. RESULTS: Ninety-six (32.0%) of the 300 sham-treated eyes with GA had an ORT at baseline. Eyes ORT at baseline lost on average 5.5 fewer Treatment Diabetic Retinopathy Study letters eyes without ORT. CONCLUSION: Sham-treated eyes with ORT at line had less loss of BCVA over 24 months eyes without ORT.