Outer Retinal Tubulation and Vision in Geographic Atrophy: A Natural History Analysis From the Phase 3 OAKS and DERBY Trials

被引：0
|
作者：
Hatcher, Kensington A. [1 ]
Shah, Birva K. [1 ]
Yu, Song [1 ]
Baumal, Caroline R. [1 ,2 ]
Sadda, Srinivas [3 ,4 ]
机构：
[1] Apellis Pharmaceut, Waltham, MA USA
[2] New England Eye Ctr, Boston, MA USA
[3] Univ Calif Los Angeles, Doheny Eye Inst, 625 S Fair Oaks Ave,Suite 280, Pasadena, CA 91105 USA
[4] Univ Calif Los Angeles, Dept Ophthalmol, Los Angeles, CA USA
来源：
OPHTHALMIC SURGERY LASERS & IMAGING RETINA | 2025年
关键词：
D O I：
10.3928/23258160-20250108-02
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
BACKGROUND AND OBJECTIVE: Outer retinal lation (ORT) is an optical coherence tomography finding in numerous chronic retinal diseases, cluding geographic atrophy (GA). The objective this study was to evaluate longitudinal best-corrected visual acuity (BCVA) outcomes in patients with GA comparing eyes with and without ORT baseline. PATIENTS AND METHODS: This post hoc longitudinal analysis assessed 300 eyes randomized to treatment in the phase 3 OAKS and DERBY trials. Mean change in BCVA over 24 months was calculated, comparing lesions with ORT versus without ORT at baseline. RESULTS: Ninety-six (32.0%) of the 300 sham-treated eyes with GA had an ORT at baseline. Eyes ORT at baseline lost on average 5.5 fewer Treatment Diabetic Retinopathy Study letters eyes without ORT. CONCLUSION: Sham-treated eyes with ORT at line had less loss of BCVA over 24 months eyes without ORT.
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页数：3
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