Association between Ambient Ultrafine Particles and Neurodevelopmental Delay in Preschoolers in Shanghai, China

被引:0
|
作者
Rong, Mengxun [1 ]
Shen, Yang [1 ]
Ge, Yihui [1 ]
Du, Wenchong [2 ]
Kan, Haidong [1 ]
Cai, Jing [1 ]
Zhao, Yan [3 ]
Hua, Jing [4 ]
机构
[1] Fudan Univ, Sch Publ Hlth, Dept Environm Hlth, Shanghai 200032, Peoples R China
[2] Nottingham Trent Univ, Dept Psychol, Nottingham NG1 4BU, England
[3] Fudan Univ, Hosp Obstet & Gynecol, Shanghai Med Sch, Shanghai 200090, Peoples R China
[4] Tongji Univ, Shanghai Matern & Infant Hosp 1, Sch Med, Shanghai 201204, Peoples R China
来源
ENVIRONMENT & HEALTH | 2024年 / 3卷 / 01期
基金
中国国家自然科学基金;
关键词
ultrafine particle; neurodevelopment; developmentaldelay; preschool children; postnatal exposure; MATTER AIR-POLLUTION; DEVELOPMENTAL DELAY; EXPOSURE; CHILDREN; NANOPARTICLES; PERSISTENT; STROKE; SKILLS; MICE;
D O I
10.1021/envhealth.4c00102
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Previous toxicological research has suggested the potential neurotoxicity of ultrafine particulate matter (UFP, particles <= 0.1 mu m in diameter). However, evidence from human beings, particularly regarding the neurodevelopmental impacts of UFP, is still limited. We enrolled 11,230 children aged 3-5.5 years from Shanghai, China. Residential UFP exposure was assessed by a land use regression model with a spatial resolution of 50 m. The neurodevelopment of preschoolers was assessed using the Ages & Stages Questionnaires, Third Edition. Generalized linear mixed models were used to examine the associations of UFP exposure with risk of suspected neurodevelopmental delay. For our participants, the median of UFP exposure was 24,478 [interquartile range (IQR): 22,773-27,657] number per cubic centimeter. We observed that each IQR increase in UFP was associated with 8% [odds ratio (OR), 1.08; 95% CI, 1.02-1.15] and 12% (OR, 1.12; 95% CI, 1.02-1.22) higher odds of suspected neurodevelopmental delay in gross and fine motor skills, respectively. These associations show a monotonically upward dose-response manner across overall UFP concentrations. Our findings suggest that UFP exposure during early childhood is associated with an increased risk of neurodevelopmental delay among Chinese preschoolers.
引用
收藏
页码:102 / 110
页数:9
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