CD4 T-cell-intrinsic IL6, but not T-cell-intrinsic IL1β, is required for Th17 differentiation and acquisition of effector resistance to immune suppression

被引：0
|
作者：
Vemulawada, Chakrapani [1 ]
Kale, Kshitija [1 ]
Crawford, Michael [1 ]
Karandikar, Nitin [1 ]
机构：
[1] Univ Iowa, Iowa City, IA 52242 USA
来源：
JOURNAL OF IMMUNOLOGY | 2024年 / 212卷 / 01期
关键词：
D O I：
10.4049/jimmunol.212.supp.1473.4657
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Elevated IL-6R on CD4+ T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions
    Saini, Chaman
    Srivastava, Rupesh K.
    Tarique, Mohd.
    Kurra, Santosh
    Khanna, Neena
    Ramesh, V.
    Sharma, Alpana
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [32] Elevated IL-6R on CD4+ T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions
    Chaman Saini
    Rupesh K. Srivastava
    Mohd. Tarique
    Santosh Kurra
    Neena Khanna
    V. Ramesh
    Alpana Sharma
    Scientific Reports, 10
  • [33] T cell intrinsic SerpinB1 and a cathepsin protease serve as yin and yang to control Th17 differentiation
    Hou, Lifei
    Cooley, Jessica
    Remold-O'Donnell, Eileen
    JOURNAL OF IMMUNOLOGY, 2014, 192
  • [34] PReS-FINAL-1003: Intrinsic cd4 and cd8 effector t cell resistance to suppression in the synovial fluid of juvenile idiopathic arthritis patients
    A Petrelli
    EJ Wehrens
    BJ Prakken
    F van Wijk
    Pediatric Rheumatology, 11 (Suppl 2)
  • [35] Differential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses
    Forbes, Elizabeth
    van Panhuys, Nicholas
    Min, Booki
    Le Gros, Graham
    IMMUNOLOGY AND CELL BIOLOGY, 2010, 88 (03): : 240 - 243
  • [36] MALT1-deficient CD4 T cells exhibit decreased IL-2 secretion and impaired Th1 and Th17 differentiation
    Kang, Sohyeong
    Huang, Yu-Husan
    Wang, Xiaoxia
    Fung, Shan-Yu
    Turvey, Stuart
    Priatel, John J.
    JOURNAL OF IMMUNOLOGY, 2016, 196
  • [37] STAT1 expression controls CD4 T cell Th1 and Th17 effector functionality during influenza virus infection
    Finn, Caroline M.
    Prokop, Emily
    Dhume, Kunal
    McKinstry, Kai
    JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
  • [38] Program for memory differentiation is CD8 T cell intrinsic and not determined by CD4 help.
    Kim, Juhyun
    Oh, Keunhee
    Ryu, Su Jeong
    Ju, Ji Min
    Jeon, Ji Yeong
    Sproule, Thomas
    Roopenian, Derry
    Choi, Eun Young
    JOURNAL OF IMMUNOLOGY, 2014, 192
  • [39] Memory programming in CD8+ T-cell differentiation is intrinsic and is not determined by CD4 help
    Kim, Juhyun
    Ryu, Su Jeong
    Oh, Keunhee
    Ju, Ji-Min
    Jeon, Ji Yeong
    Nam, Giri
    Lee, Dong-Sup
    Kim, Hang-Rae
    Kim, Joo Young
    Chang, Jun
    Sproule, Thomas
    Choi, Kyungho
    Roopenian, Derry
    Choi, Eun Young
    NATURE COMMUNICATIONS, 2015, 6
  • [40] Memory programming in CD8+ T-cell differentiation is intrinsic and is not determined by CD4 help
    Juhyun Kim
    Su Jeong Ryu
    Keunhee Oh
    Ji-Min Ju
    Ji Yeong Jeon
    Giri Nam
    Dong-Sup Lee
    Hang-Rae Kim
    Joo Young Kim
    Jun Chang
    Thomas Sproule
    Kyungho Choi
    Derry Roopenian
    Eun Young Choi
    Nature Communications, 6
12345