SLCO1B1 variants in a patient of African ancestry presenting with rosuvastatin-induced rhabdomyolysis: A case report

被引：1
|
作者：
Medwid, Samantha [1 ]
Deckert, Rowan [1 ]
Gryn, Steven E. [1 ,2 ]
Kim, Richard B. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Western Ontario, Dept Med, London, ON, Canada
[2] London Hlth Sci Ctr, London, ON, Canada
[3] Western Univ, Dept Physiol & Pharmacol, London, ON, Canada
[4] Lawson Hlth Res Inst, London, ON, Canada
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2025年 / 91卷 / 01期
关键词：
statins; rhabdomyolysis; pharmacogenetics; DRUG; POLYMORPHISMS; TRANSPORTERS;
D O I：
10.1111/bcp.16329
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We report a case of an adult woman of African ancestry who was hospitalized with statin induced- rhabdomyolysis. The patient presented to the emergency room with a 2-week history of worsening muscle pain, nausea, vomiting and low oral intake, 1 month after starting 40 mg daily dose of rosuvastatin. Sequencing of SLCO1B1 coding regions revealed the patient was heterozygous for two SLCO1B1 deleterious variants, c.481+1G>T and c.1463G>C (*9), which are more prevalent in patients of African ancestry. This highlights the importance of pharmacogenetic testing in SLCO1B1, which includes a broader range of genetic variants for patients of African ancestry.
引用
收藏
页码：232 / 235
页数：4
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