Imaging Features of Immunodeficiency-Associated Primary CNS Lymphoma: A Review

被引:0
|
作者
Omid-Fard, Nima [1 ]
Puac-Polanco, Paulo [1 ]
Torres, Carlos Hernando [1 ]
Hamilton, Leslie [2 ]
Nguyen, Thanh Binh [1 ]
机构
[1] Univ Ottawa, Dept Radiol Radiat Oncol & Med Phys, 1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada
[2] Univ Ottawa, Dept Anat Pathol, Ottawa, ON, Canada
来源
CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES | 2025年 / 76卷 / 01期
关键词
lymphoma; CNS; central nervous system; neuroradiology; immunocompromised; immunodeficient; EBV; GBM; CENTRAL-NERVOUS-SYSTEM; DIAGNOSTIC PERFORMANCE; ELDERLY-PATIENTS; MR SPECTROSCOPY; DIFFERENTIATION; GRANULOMATOSIS; GLIOBLASTOMAS; DIFFUSION;
D O I
10.1177/08465371241259951
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
In the immunocompromised setting, there are distinct radiologic findings of primary central nervous system lymphoma (PCNSL), including necrotic ring-enhancing lesions, increased propensity for intralesional haemorrhage, and multiplicity. In this clinical context, advanced imaging with MR perfusion, spectroscopy, and diffusion-weighted imaging can be used to increase accuracy in the diagnosis of lymphoma over mimics such as high-grade glioma, metastases, or infection. This review summarizes the histology and pathophysiology of PCNSL in immunodeficient hosts, which provide a basis for its imaging appearances, prognosis, and treatment. This discussion is important for the general radiologist as the incidence of immunodeficiency-related PCNSL may be increasing. Dans un contexte d'immunovuln & eacute;rabilit & eacute;, le lymphome primitif du syst & egrave;me nerveux central (LPSNC) pr & eacute;sente des caract & eacute;ristiques radiologiques distinctes, notamment des l & eacute;sions n & eacute;crotiques pr & eacute;sentant un rehaussement annulaire, une propension accrue aux h & eacute;morragies intral & eacute;sionnelles et la multiplicit & eacute; des l & eacute;sions. Dans ce contexte clinique, une imagerie avanc & eacute;e au moyen d'une IRM de perfusion, de la spectroscopie et de l'imagerie de diffusion peut & ecirc;tre utilis & eacute;e pour augmenter la pr & eacute;cision du diagnostic de lymphome par rapport aux affections de caract & eacute;ristiques radiologiques similaires telles que le gliome de haut grade, les m & eacute;tastases ou les infections. Cet article de revue r & eacute;sume l'histologie et la physiopathologie du LPSNC chez les h & ocirc;tes immunovuln & eacute;rables, qui fournissent une base pour l'imagerie, le pronostic et le traitement. Cette discussion est importante pour le radiologiste g & eacute;n & eacute;raliste, car l'incidence du LPSNC li & eacute; & agrave; l'immunovuln & eacute;rabilit & eacute; pourrait & ecirc;tre en augmentation.
引用
收藏
页码:113 / 121
页数:9
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