Avelumab plus axitinib (A plus Ax) vs sunitinib (S) in patients (pts) with advanced renal cell carcinoma (aRCC): Subgroup analyses by age from the final analysis of the phase III JAVELIN Renal 101 trial

被引:0
|
作者
Oya, M. [1 ]
Motzer, R. J. [2 ]
Choueiri, T. K. [3 ]
Haanen, J. B. A. G. [4 ]
Eto, M. [5 ]
Uemura, H. [6 ]
Venugopal, B. [7 ]
Rini, B. I. [8 ]
Miyake, H. [9 ]
Albiges, L. [10 ]
Schmidinger, M. [11 ]
Tomita, Y. [12 ,13 ]
Umeyama, Y. [14 ]
Ellers-Lenz, B. [15 ]
Hoffman, J. [16 ]
Larkin, J. [17 ]
机构
[1] Keio Univ, Sch Med, Dept Urol, Tokyo, Japan
[2] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
[3] Dana Farber Canc Inst, Lank Ctr Genitourinary Oncol, Boston, MA 02115 USA
[4] Netherlands Canc Inst, Amsterdam, Netherlands
[5] Kyushu Univ, Grad Sch Med Sci, Dept Urol, Fukuoka, Japan
[6] Kindai Univ, Fac Med, Dept Urol, Osakasayama, Japan
[7] Univ Glasgow, Beatson West Scotland Canc Ctr, Glasgow, Lanark, Scotland
[8] Vanderbilt Ingram Canc Ctr, Nashville, TN USA
[9] Kobe Univ, Grad Sch Med, Div Urol, Kobe, Hyogo, Japan
[10] Inst Gustave Roussy, Villejuif, France
[11] Med Univ Vienna, Vienna, Austria
[12] Niigata Univ, Grad Sch Med, Dept Urol, Niigata, Japan
[13] Niigata Univ, Grad Sch Med, Dept Mol Oncol, Niigata, Japan
[14] Pfizer Japan Inc, Clin & Res Dept, Oncol, Shibuya Ku, Tokyo, Japan
[15] Merck Healthcare KGaA, Darmstadt, Germany
[16] EMD Serono Res & Dev Inst Inc, Billerica, MA USA
[17] Royal Marsden Hosp, London, England
关键词
D O I
10.1016/j.annonc.2024.10.312
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
292P
引用
收藏
页码:S1517 / S1518
页数:2
相关论文
共 50 条
  • [41] Final Analysis of Post-Marketing Surveillance for Avelumab plus Axitinib in Patients With Renal Cell Carcinoma in Japan
    Nonomura, Norio
    Ito, Taito
    Sato, Masashi
    Morita, Makiko
    Ogi, Mie
    Kajita, Masahiro
    Oya, Mototsugu
    CANCER MEDICINE, 2025, 14 (02):
  • [42] Lenvatinib plus pembrolizumab (L plus P) vs sunitinib (S) in advanced renal cell carcinoma (aRCC): Patterns of progression and subsequent therapy in the CLEAR trial
    Grunwald, Viktor
    Motzer, Robert J.
    Keizman, Daniel
    Bedke, Jens
    Schmidinger, Manuela
    Staehler, Michael D.
    Matveev, Vsevolod B.
    George, Saby
    Hutson, Thomas E.
    Vaishampayan, Ulka N.
    Merchan, Jaime R.
    Eto, Masatoshi
    Rha, Sun Young
    Waddell, Tom
    Sabbatini, Roberto
    Barthelemy, Philippe
    Burgents, Joseph E.
    Ren, Min
    Brown, Ian
    Choueiri, Toni K.
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [43] Phase 3 study of avelumab in combination with axitinib versus sunitinib as first-line treatment for patients with advanced renal cell carcinoma (aRCC)
    Motzer, R. J.
    Choueiri, T.
    Larkin, J.
    Albiges, L.
    Haanen, J. B.
    Schmidinger, M.
    Atkins, M. B.
    Mariani, M.
    Shnaidman, M.
    Di Pietro, A.
    Rini, B. I.
    ANNALS OF ONCOLOGY, 2016, 27
  • [44] Axitinib in combination with pembrolizumab (AXI plus PEMBRO) in patients (pts) with advanced renal cell carcinoma (aRCC): Analysis of immune-related biomarkers
    Atkins, Michael
    Martini, Jean-Francois
    Plimack, Elizabeth
    McDermott, David
    Puzanov, Igor
    Fishman, Mayer
    Cho, Daniel
    Vaishampayan, Ulka
    Rosbrook, Brad
    Fernandez, Kathrine
    Tarazi, Jamal
    George, Saby
    Choueiri, Toni
    CANCER RESEARCH, 2019, 79 (13)
  • [45] A UK real-world observational study of avelumab plus axitinib (A plus Ax) in advanced renal cell carcinoma (aRCC): Outcomes at 36 months post treatment initiation.
    Nathan, Paul D.
    Charnley, Natalie
    Frazer, Ricky
    McGrane, John
    Muazzam, Iqtedar
    Pillai, Manon
    Rudman, Sarah
    Stevenson, Robert
    Venugopal, Balaji
    Hickey, Joseph David
    Ritchie, Aimi Rose
    Liu, Kin
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (4_SUPPL) : 386 - 386
  • [46] Avelumab plus axitinib (Ave plus Axi) vs sunitinib (Sun) in advanced renal cell carcinoma (aRCC): Final analysis of patient (pt)-reported outcomes (PROs) and quality-adjusted time without symptoms or toxicity (Q-TWiST)
    Venugopal, B.
    Choueiri, T. K.
    Penkov, K. D.
    Albiges, L.
    Uemura, H.
    Larkin, J.
    Tomita, Y.
    Wang, J.
    Hoffman, J.
    Gerhold-Ay, A.
    Kieslich, P.
    Motzer, R. J.
    ANNALS OF ONCOLOGY, 2024, 35 : S1017 - S1018
  • [47] Post-marketing surveillance data for avelumab plus axitinib treatment in patients with advanced renal cell carcinoma in Japan: Subgroup analyses by pathological classification
    Nonomura, Norio
    Ito, Taito
    Sato, Masashi
    Morita, Makiko
    Kajita, Masahiro
    Oya, Mototsugu
    INTERNATIONAL JOURNAL OF UROLOGY, 2025, 32 (03) : 293 - 299
  • [48] Updated efficacy of lenvatinib (LEN) plus pembrolizumab (PEMBRO) vs sunitinib (SUN) in patients (pts) with advanced renal cell carcinoma (aRCC) in the CLEAR study
    Porta, C. G.
    Eto, M.
    Motzer, R. J.
    De Giorgi, U. F. F.
    Buchler, T.
    Basappa, N. S.
    Mendez Vidal, M. J.
    Tjulandin, S.
    Park, S. H.
    Melichar, B.
    Hutson, T. E.
    Alemany, C.
    McGregor, B.
    He, C. S.
    Perini, R.
    Mody, K.
    McKenzie, J.
    Choueiri, T. K.
    ANNALS OF ONCOLOGY, 2022, 33 (07) : S1205 - +
  • [49] Final prespecified overall survival (OS) analysis of CLEAR: 4-year follow-up of lenvatinib plus pembrolizumab (L plus P) vs sunitinib (S) in patients (pts) with advanced renal cell carcinoma (aRCC)
    Motzer, Robert J.
    Porta, Camillo
    Eto, Masatoshi
    Powles, Thomas
    Gruenwald, Viktor
    Hutson, Thomas E.
    Alekseev, Boris
    Rha, Sun Young
    Merchan, Jaime R.
    Goh, Jeffrey C.
    Kapoor, Anil
    De Giorgi, Ugo
    Melichar, Bohuslav
    Hong, Sung-Hoo
    Gurney, Howard
    Rodriguez-Lopez, Karla
    He, Cixin S.
    Okpara, Chinyere
    McKenzie, Jodi
    Choueiri, Toni K.
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [50] Characterization of response to nivolumab plus ipilimumab (N plus I) or sunitinib (S) in patients (Pts) with previously untreated advanced renal cell carcinoma (arcc): Checkmate 214
    Rini, B. I.
    Tannir, N. M.
    Escudier, B.
    McDermott, D. F.
    Grimm, M-O.
    Porta, C.
    Powles, T.
    Kollmannsberger, C. K.
    Gurney, H. P.
    Tykodi, S. S.
    Harrison, M.
    Heng, D. Y. C.
    Gruenwald, V.
    Choueiri, T. K.
    Mekan, S.
    McHenry, M. B.
    Hammers, H. J.
    Motzer, R. J.
    George, S.
    ANNALS OF ONCOLOGY, 2018, 29