The role of moderate to vigorous physical activity level and number of treatments/medications in mediating the effect of body mass index on diabetic nephropathy: a Mendelian randomization study

被引：0
|
作者：
Hu, Shasha [1 ]
Chen, Yuling [1 ]
He, Mingjie [1 ]
Wen, Jun [1 ]
Zhong, Aimin [1 ]
Zhan, Dandan [1 ]
Ye, Zhibin [2 ]
机构：
[1] First Affiliated Hosp, Jiangxi Prov Peoples Hosp, Nanchang Med Coll, Dept Nephrol, Nanchang, Jiangxi, Peoples R China
[2] Fudan Univ, Dept Nephrol, Huadong Hosp Affiliated, Shanghai, Peoples R China
来源：
RENAL FAILURE | 2024年 / 46卷 / 02期
关键词：
Body mass index; diabetic nephropathy; Mendelian randomization; mediation effect; type; 2; diabetes; KIDNEY-DISEASE; INSTRUMENTS; OBESITY; INTERVENTION; INFLAMMATION; ADULTS; RISK;
D O I：
10.1080/0886022X.2024.2417738
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
BackgroundBody mass index (BMI) is associated with diabetic nephropathy (DN). However, the mediator factors in the BMI-DN effects remain unclear.MethodsUnivariate and multivariate Mendelian randomization (MR) analysis were performed to estimate the association between six lifestyles (moderate to vigorous physical activity levels, years of schooling, BMI, nap during day, number of treatments/medications taken and coffee intake) and DN. MR Egger, Weighted median, Simple mode, and Weighted mode was supplemental methods to Inverse variance weighted. Sensitivity analysis included heterogeneity test, horizontal pleiotropy test, and Leave-One-Out. Additionally, mediation MR was conducted to evaluate the mediating role of lifestyles between BMI and DN. Finally, functional enrichment analysis based on the mediation MR results was performed.Resultsunivariate and multivariate Mendelian randomization (MR) analysis were performed to estimate the association between six lifestyles (moderate to vigorous physical activity levels, years of schooling, BMI, nap during day, number of treatments/medications taken and coffee intake) and DN. MR Egger, Weighted median, Simple mode, and Weighted mode was supplemental methods to Inverse variance weighted. Sensitivity analysis included heterogeneity test, horizontal pleiotropy test, and Leave-One-Out. Additionally, mediation MR was conducted to evaluate the mediating role of lifestyles between BMI and DN. Finally, functional enrichment analysis based on the mediation MR results was performed.Conclusionour results supported mediation role of vigorous physical activity level and number of treatments/medications in BMI-DN effects.
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页数：13
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